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Page 1
Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs.
Kastan NR, Oak S, Liang R, Baxt L, Myers RW, Ginn J, Liverton N, Huggins DJ, Pichardo J, Paul M, Carroll TS, Nagiel A, Gnedeva K, Hudspeth AJ. Kastan NR, et al. Among authors: baxt l. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2206113119. doi: 10.1073/pnas.2206113119. Epub 2022 Jul 8. Proc Natl Acad Sci U S A. 2022. PMID: 35867764 Free PMC article.
A Chemical Strategy toward Novel Brain-Penetrant EZH2 Inhibitors.
Liang R, Tomita D, Sasaki Y, Ginn J, Michino M, Huggins DJ, Baxt L, Kargman S, Shahid M, Aso K, Duggan M, Stamford AW, DeStanchina E, Liverton N, Meinke PT, Foley MA, Phillips RE. Liang R, et al. Among authors: baxt l. ACS Med Chem Lett. 2022 Feb 10;13(3):377-387. doi: 10.1021/acsmedchemlett.1c00448. eCollection 2022 Mar 10. ACS Med Chem Lett. 2022. PMID: 35300079 Free PMC article.
Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors.
Michino M, Beautrait A, Boyles NA, Nadupalli A, Dementiev A, Sun S, Ginn J, Baxt L, Suto R, Bryk R, Jerome SV, Huggins DJ, Vendome J. Michino M, et al. Among authors: baxt l. ACS Bio Med Chem Au. 2023 Sep 8;3(6):507-515. doi: 10.1021/acsbiomedchemau.3c00046. eCollection 2023 Dec 20. ACS Bio Med Chem Au. 2023. PMID: 38144256 Free PMC article.
Next Generation Neuropeptide Y Receptor Small Molecule Agonists Inhibit Mosquito Biting Behavior.
Zeledon EV, Baxt LA, Khan TA, Michino M, Miller M, Huggins DJ, Jiang CS, Vosshall LB, Duvall LB. Zeledon EV, et al. Among authors: baxt la. bioRxiv [Preprint]. 2024 Mar 5:2024.02.28.582529. doi: 10.1101/2024.02.28.582529. bioRxiv. 2024. Update in: Parasit Vectors. 2024 Jun 28;17(1):276. doi: 10.1186/s13071-024-06347-w PMID: 38464241 Free PMC article. Updated. Preprint.
Indazole to 2-Cyanoindole Scaffold Progression for Mycobacterial Lipoamide Dehydrogenase Inhibitors Achieves Extended Target Residence Time and Improved Antibacterial Activity.
Sun S, Ginn J, Kochanczyk T, Arango N, Jiang X, Huggins DJ, Bean J, Michino M, Baxt L, Liverton N, Meinke PT, Bryk R. Sun S, et al. Among authors: baxt l. Angew Chem Int Ed Engl. 2024 Oct 24;63(44):e202407276. doi: 10.1002/anie.202407276. Epub 2024 Sep 20. Angew Chem Int Ed Engl. 2024. PMID: 38997232
Intermediate filaments enable pathogen docking to trigger type 3 effector translocation.
Russo BC, Stamm LM, Raaben M, Kim CM, Kahoud E, Robinson LR, Bose S, Queiroz AL, Herrera BB, Baxt LA, Mor-Vaknin N, Fu Y, Molina G, Markovitz DM, Whelan SP, Goldberg MB. Russo BC, et al. Among authors: baxt la. Nat Microbiol. 2016 Mar 7;1:16025. doi: 10.1038/nmicrobiol.2016.25. Nat Microbiol. 2016. PMID: 27572444 Free PMC article.
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