Khojasteh SC - Search Results

1

Bioactivation and reactivity research advances - 2021 year in review.

Jackson KD, Argikar UA, Cho S, Crouch RD, Driscoll JP, Heck CJS, King L, Maw HH, Miller GP, Seneviratne HK, Wang S, Wei C, Zhang D, Khojasteh SC. Jackson KD, et al. Among authors: khojasteh sc. Drug Metab Rev. 2022 Aug;54(3):246-281. doi: 10.1080/03602532.2022.2097254. Epub 2022 Aug 5. Drug Metab Rev. 2022. PMID: 35876116 Free PMC article. Review.

2

High-throughput, 384-well, LC-MS/MS CYP inhibition assay using automation, cassette-analysis technique, and streamlined data analysis.

Halladay JS, Delarosa EM, Tran D, Wang L, Wong S, Khojasteh SC. Halladay JS, et al. Among authors: khojasteh sc. Drug Metab Lett. 2011 Aug;5(3):220-30. Drug Metab Lett. 2011. PMID: 21867481

3

Novel mechanism for dehalogenation and glutathione conjugation of dihalogenated anilines in human liver microsomes: evidence for ipso glutathione addition.

Zhang C, Kenny JR, Le H, Deese A, Ford KA, Lightning LK, Fan PW, Driscoll JP, Halladay JS, Hop CE, Khojasteh SC. Zhang C, et al. Among authors: khojasteh sc. Chem Res Toxicol. 2011 Oct 17;24(10):1668-77. doi: 10.1021/tx2002228. Epub 2011 Sep 25. Chem Res Toxicol. 2011. PMID: 21905702

4

Evaluation of time-dependent cytochrome p450 inhibition in a high-throughput, automated assay: introducing a novel area under the curve shift approach.

Mukadam S, Tay S, Tran D, Wang L, Delarosa EM, Khojasteh SC, Halladay JS, Kenny JR. Mukadam S, et al. Among authors: khojasteh sc. Drug Metab Lett. 2012 Mar;6(1):43-53. doi: 10.2174/187231212800229309. Drug Metab Lett. 2012. PMID: 22372554

5

Investigations into the mechanisms of pyridine ring cleavage in vismodegib.

Khojasteh SC, Yue Q, Ma S, Castanedo G, Chen JZ, Lyssikatos J, Mulder T, Takahashi R, Ly J, Messick K, Jia W, Liu L, Hop CE, Wong H. Khojasteh SC, et al. Drug Metab Dispos. 2014 Mar;42(3):343-51. doi: 10.1124/dmd.113.055715. Epub 2014 Jan 3. Drug Metab Dispos. 2014. PMID: 24389420

6

1-Aminobenzotriazole coincubated with (S)-warfarin results in potent inactivation of CYP2C9.

Sodhi JK, Ford KA, Mukadam S, Wong S, Hop CE, Khojasteh SC, Halladay JS. Sodhi JK, et al. Among authors: khojasteh sc. Drug Metab Dispos. 2014 May;42(5):813-7. doi: 10.1124/dmd.113.055913. Epub 2014 Feb 18. Drug Metab Dispos. 2014. PMID: 24550229

7

Non-Clinical Disposition and Metabolism of DM1, a Component of Trastuzumab Emtansine (T-DM1), in Sprague Dawley Rats.

Shen BQ, Bumbaca D, Yue Q, Saad O, Tibbitts J, Khojasteh SC, Girish S. Shen BQ, et al. Among authors: khojasteh sc. Drug Metab Lett. 2015;9(2):119-31. doi: 10.2174/1872312809666150602151922. Drug Metab Lett. 2015. PMID: 26031461

8

Elucidating the Mechanisms of Formation for Two Unusual Cytochrome P450-Mediated Fused Ring Metabolites of GDC-0623, a MAPK/ERK Kinase Inhibitor.

Takahashi RH, Ma S, Robinson SJ, Yue Q, Choo EF, Khojasteh SC. Takahashi RH, et al. Among authors: khojasteh sc. Drug Metab Dispos. 2015 Dec;43(12):1929-33. doi: 10.1124/dmd.115.067181. Epub 2015 Oct 5. Drug Metab Dispos. 2015. PMID: 26438627

9

Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans.

Takahashi RH, Choo EF, Ma S, Wong S, Halladay J, Deng Y, Rooney I, Gates M, Hop CE, Khojasteh SC, Dresser MJ, Musib L. Takahashi RH, et al. Among authors: khojasteh sc. Drug Metab Dispos. 2016 Jan;44(1):28-39. doi: 10.1124/dmd.115.066282. Epub 2015 Oct 8. Drug Metab Dispos. 2016. PMID: 26451002 Clinical Trial.

10

Going Beyond Common Drug Metabolizing Enzymes: Case Studies of Biotransformation Involving Aldehyde Oxidase, γ-Glutamyl Transpeptidase, Cathepsin B, Flavin-Containing Monooxygenase, and ADP-Ribosyltransferase.

Fan PW, Zhang D, Halladay JS, Driscoll JP, Khojasteh SC. Fan PW, et al. Among authors: khojasteh sc. Drug Metab Dispos. 2016 Aug;44(8):1253-61. doi: 10.1124/dmd.116.070169. Epub 2016 Apr 26. Drug Metab Dispos. 2016. PMID: 27117704 Review.

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