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Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin alpha(M)beta(2) engagement of fibrinogen.
Steinbrecher KA, Horowitz NA, Blevins EA, Barney KA, Shaw MA, Harmel-Laws E, Finkelman FD, Flick MJ, Pinkerton MD, Talmage KE, Kombrinck KW, Witte DP, Palumbo JS. Steinbrecher KA, et al. Among authors: palumbo js. Cancer Res. 2010 Apr 1;70(7):2634-43. doi: 10.1158/0008-5472.CAN-09-3465. Epub 2010 Mar 16. Cancer Res. 2010. PMID: 20233870 Free PMC article.
The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A.
Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, Wagner DD, Degen JL. Flick MJ, et al. Among authors: palumbo js. Blood. 2011 Jun 9;117(23):6326-37. doi: 10.1182/blood-2010-08-304915. Epub 2011 Mar 24. Blood. 2011. PMID: 21436072 Free PMC article.
Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain.
Horowitz NA, Blevins EA, Miller WM, Perry AR, Talmage KE, Mullins ES, Flick MJ, Queiroz KC, Shi K, Spek CA, Conway EM, Monia BP, Weiler H, Degen JL, Palumbo JS. Horowitz NA, et al. Among authors: palumbo js. Blood. 2011 Sep 8;118(10):2889-95. doi: 10.1182/blood-2011-03-341222. Epub 2011 Jul 25. Blood. 2011. PMID: 21788337 Free PMC article.
223 results