Zhan L - Search Results

1

SCN8A epileptic encephalopathy mutations display a gain-of-function phenotype and divergent sensitivity to antiepileptic drugs.

Guo QB, Zhan L, Xu HY, Gao ZB, Zheng YM. Guo QB, et al. Among authors: zhan l. Acta Pharmacol Sin. 2022 Dec;43(12):3139-3148. doi: 10.1038/s41401-022-00955-x. Epub 2022 Jul 27. Acta Pharmacol Sin. 2022. PMID: 35902765 Free PMC article.

2

P-retigabine: an N-propargyled retigabine with improved brain distribution and enhanced antiepileptic activity.

Zhou P, Zhang Y, Xu H, Chen F, Chen X, Li X, Pi X, Wang L, Zhan L, Nan F, Gao Z. Zhou P, et al. Among authors: zhan l. Mol Pharmacol. 2015 Jan;87(1):31-8. doi: 10.1124/mol.114.095190. Epub 2014 Oct 15. Mol Pharmacol. 2015. PMID: 25319542

3

Activation of peripheral KCNQ channels relieves gout pain.

Zheng Y, Xu H, Zhan L, Zhou X, Chen X, Gao Z. Zheng Y, et al. Among authors: zhan l. Pain. 2015 Jun;156(6):1025-1035. doi: 10.1097/j.pain.0000000000000122. Pain. 2015. PMID: 25735002 Free PMC article.

4

Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels.

Xie ZQ, Tian XT, Zheng YM, Zhan L, Chen XQ, Xin XM, Huang CG, Gao ZB. Xie ZQ, et al. Among authors: zhan l. Acta Pharmacol Sin. 2020 May;41(5):629-637. doi: 10.1038/s41401-019-0327-4. Epub 2020 Jan 7. Acta Pharmacol Sin. 2020. PMID: 31911638 Free PMC article.

5

Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate.

Zhang YM, Xu HY, Hu HN, Tian FY, Chen F, Liu HN, Zhan L, Pi XP, Liu J, Gao ZB, Nan FJ. Zhang YM, et al. Among authors: zhan l. J Med Chem. 2021 May 13;64(9):5816-5837. doi: 10.1021/acs.jmedchem.0c02252. Epub 2021 Apr 30. J Med Chem. 2021. PMID: 33929863

6

(-)-Naringenin 4',7-dimethyl Ether Isolated from Nardostachys jatamansi Relieves Pain through Inhibition of Multiple Channels.

Gu RR, Meng XH, Zhang Y, Xu HY, Zhan L, Gao ZB, Yang JL, Zheng YM. Gu RR, et al. Among authors: zhan l. Molecules. 2022 Mar 7;27(5):1735. doi: 10.3390/molecules27051735. Molecules. 2022. PMID: 35268839 Free PMC article.

7

Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors.

Zeng Y, Zheng Y, Zhang T, Ye F, Zhan L, Kou Z, Zhu S, Gao Z. Zeng Y, et al. Among authors: zhan l. Front Pharmacol. 2022 Jun 9;13:888308. doi: 10.3389/fphar.2022.888308. eCollection 2022. Front Pharmacol. 2022. PMID: 35754487 Free PMC article.

8

Epilepsy phenotype and response to KCNQ openers in mice harboring the Kcnq2 R207W voltage-sensor mutation.

Tian F, Cao B, Xu H, Zhan L, Nan F, Li N, Taglialatela M, Gao Z. Tian F, et al. Among authors: zhan l. Neurobiol Dis. 2022 Nov;174:105860. doi: 10.1016/j.nbd.2022.105860. Epub 2022 Sep 14. Neurobiol Dis. 2022. PMID: 36113748 Free article.

9

Prime editing-based gene correction alleviates the hyperexcitable phenotype and seizures of a genetic epilepsy mouse model.

Cao BR, Huang YM, Tian FY, Li JH, Xu CL, Wei Y, Liu JK, Guo QB, Xu HY, Zhan L, Lv RM, Sun YD, Hu XD, Gao ZB, Zhou CY. Cao BR, et al. Among authors: zhan l. Acta Pharmacol Sin. 2023 Nov;44(11):2342-2345. doi: 10.1038/s41401-023-01115-5. Epub 2023 Jul 4. Acta Pharmacol Sin. 2023. PMID: 37402996 Free PMC article. No abstract available.

10

Pharmacological inhibition of Kir4.1 evokes rapid-onset antidepressant responses.

Zhou X, Zhao C, Xu H, Xu Y, Zhan L, Wang P, He J, Lu T, Gu Y, Yang Y, Xu C, Chen Y, Liu Y, Zeng Y, Tian F, Chen Q, Xie X, Liu J, Hu H, Li J, Zheng Y, Guo J, Gao Z. Zhou X, et al. Among authors: zhan l. Nat Chem Biol. 2024 Jul;20(7):857-866. doi: 10.1038/s41589-024-01555-y. Epub 2024 Feb 14. Nat Chem Biol. 2024. PMID: 38355723

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