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Mesenchymal stromal cells engineered to produce IGF-I by recombinant adenovirus ameliorate liver fibrosis in mice.
Fiore EJ, Bayo JM, Garcia MG, Malvicini M, Lloyd R, Piccioni F, Rizzo M, Peixoto E, Sola MB, Atorrasagasti C, Alaniz L, Camilletti MA, Enguita M, Prieto J, Aquino JB, Mazzolini G. Fiore EJ, et al. Among authors: aquino jb. Stem Cells Dev. 2015 Mar 15;24(6):791-801. doi: 10.1089/scd.2014.0174. Epub 2014 Dec 3. Stem Cells Dev. 2015. PMID: 25315017 Free PMC article.
Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice.
Atorrasagasti C, Peixoto E, Aquino JB, Kippes N, Malvicini M, Alaniz L, Garcia M, Piccioni F, Fiore EJ, Bayo J, Bataller R, Guruceaga E, Corrales F, Podhajcer O, Mazzolini G. Atorrasagasti C, et al. Among authors: aquino jb. PLoS One. 2013;8(2):e54962. doi: 10.1371/journal.pone.0054962. Epub 2013 Feb 11. PLoS One. 2013. PMID: 23408952 Free PMC article.
SPARC downregulation attenuates the profibrogenic response of hepatic stellate cells induced by TGF-β1 and PDGF.
Atorrasagasti C, Aquino JB, Hofman L, Alaniz L, Malvicini M, Garcia M, Benedetti L, Friedman SL, Podhajcer O, Mazzolini G. Atorrasagasti C, et al. Among authors: aquino jb. Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G739-48. doi: 10.1152/ajpgi.00316.2010. Epub 2011 Feb 10. Am J Physiol Gastrointest Liver Physiol. 2011. PMID: 21311029 Free PMC article.
Positional differences of axon growth rates between sensory neurons encoded by Runx3.
Lallemend F, Sterzenbach U, Hadjab-Lallemend S, Aquino JB, Castelo-Branco G, Sinha I, Villaescusa JC, Levanon D, Wang Y, Franck MC, Kharchenko O, Adameyko I, Linnarsson S, Groner Y, Turner E, Ernfors P. Lallemend F, et al. Among authors: aquino jb. EMBO J. 2012 Sep 12;31(18):3718-29. doi: 10.1038/emboj.2012.228. Epub 2012 Aug 17. EMBO J. 2012. PMID: 22903063 Free PMC article.
Adenovirus-mediated inhibition of SPARC attenuates liver fibrosis in rats.
Camino AM, Atorrasagasti C, Maccio D, Prada F, Salvatierra E, Rizzo M, Alaniz L, Aquino JB, Podhajcer OL, Silva M, Mazzolini G. Camino AM, et al. Among authors: aquino jb. J Gene Med. 2008 Sep;10(9):993-1004. doi: 10.1002/jgm.1228. J Gene Med. 2008. PMID: 18615449
SPARC (secreted protein acidic and rich in cysteine) knockdown protects mice from acute liver injury by reducing vascular endothelial cell damage.
Peixoto E, Atorrasagasti C, Aquino JB, Militello R, Bayo J, Fiore E, Piccioni F, Salvatierra E, Alaniz L, García MG, Bataller R, Corrales F, Gidekel M, Podhajcer O, Colombo MI, Mazzolini G. Peixoto E, et al. Among authors: aquino jb. Gene Ther. 2015 Jan;22(1):9-19. doi: 10.1038/gt.2014.102. Epub 2014 Nov 20. Gene Ther. 2015. PMID: 25410742 Free PMC article.
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