Al-Karmalawy AA - Search Results

1

Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease.

Elagawany M, Elmaaty AA, Mostafa A, Abo Shama NM, Santali EY, Elgendy B, Al-Karmalawy AA. Elagawany M, et al. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2112-2132. doi: 10.1080/14756366.2022.2105322. J Enzyme Inhib Med Chem. 2022. PMID: 35912578 Free PMC article.

2

Molecular docking, molecular dynamics, and in vitro studies reveal the potential of angiotensin II receptor blockers to inhibit the COVID-19 main protease.

Alnajjar R, Mostafa A, Kandeil A, Al-Karmalawy AA. Alnajjar R, et al. Heliyon. 2020 Dec;6(12):e05641. doi: 10.1016/j.heliyon.2020.e05641. Epub 2020 Dec 3. Heliyon. 2020. PMID: 33294721 Free PMC article.

3

In a search for potential drug candidates for combating COVID-19: computational study revealed salvianolic acid B as a potential therapeutic targeting 3CLpro and spike proteins.

Elmaaty AA, Darwish KM, Khattab M, Elhady SS, Salah M, Hamed MIA, Al-Karmalawy AA, Saleh MM. Elmaaty AA, et al. J Biomol Struct Dyn. 2022;40(19):8866-8893. doi: 10.1080/07391102.2021.1918256. Epub 2021 Apr 30. J Biomol Struct Dyn. 2022. PMID: 33928870

4

Strong Inhibitory Activity and Action Modes of Synthetic Maslinic Acid Derivative on Highly Pathogenic Coronaviruses: COVID-19 Drug Candidate.

Soltane R, Chrouda A, Mostafa A, Al-Karmalawy AA, Chouaïb K, Dhahri A, Pashameah RA, Alasiri A, Kutkat O, Shehata M, Jannet HB, Gharbi J, Ali MA. Soltane R, et al. Pathogens. 2021 May 19;10(5):623. doi: 10.3390/pathogens10050623. Pathogens. 2021. PMID: 34069460 Free PMC article.

5

From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity.

El-Shershaby MH, Ghiaty A, Bayoumi AH, Al-Karmalawy AA, Husseiny EM, El-Zoghbi MS, Abulkhair HS. El-Shershaby MH, et al. Bioorg Med Chem. 2021 Jul 15;42:116266. doi: 10.1016/j.bmc.2021.116266. Epub 2021 Jun 5. Bioorg Med Chem. 2021. PMID: 34126285

6

Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2.

Kandeil A, Mostafa A, Kutkat O, Moatasim Y, Al-Karmalawy AA, Rashad AA, Kayed AE, Kayed AE, El-Shesheny R, Kayali G, Ali MA. Kandeil A, et al. Pathogens. 2021 Jun 15;10(6):758. doi: 10.3390/pathogens10060758. Pathogens. 2021. PMID: 34203977 Free PMC article.

7

Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization.

Abo Elmaaty A, Hamed MIA, Ismail MI, B Elkaeed E, S Abulkhair H, Khattab M, Al-Karmalawy AA. Abo Elmaaty A, et al. Molecules. 2021 Jun 21;26(12):3772. doi: 10.3390/molecules26123772. Molecules. 2021. PMID: 34205704 Free PMC article.

8

Telaprevir is a potential drug for repurposing against SARS-CoV-2: computational and in vitro studies.

Mahmoud A, Mostafa A, Al-Karmalawy AA, Zidan A, Abulkhair HS, Mahmoud SH, Shehata M, Elhefnawi MM, Ali MA. Mahmoud A, et al. Heliyon. 2021 Sep;7(9):e07962. doi: 10.1016/j.heliyon.2021.e07962. Epub 2021 Sep 9. Heliyon. 2021. PMID: 34518806 Free PMC article.

9

Delineating a potent antiviral activity of Cuphea ignea extract loaded nano-formulation against SARS-CoV-2: In silico and in vitro studies.

Mahmoud DB, Ismail WM, Moatasim Y, Kutkat O, ElMeshad AN, Ezzat SM, El Deeb KS, El-Fishawy AM, Gomaa MR, Kandeil A, Al-Karmalawy AA, Ali MA, Mostafa A. Mahmoud DB, et al. J Drug Deliv Sci Technol. 2021 Dec;66:102845. doi: 10.1016/j.jddst.2021.102845. Epub 2021 Sep 15. J Drug Deliv Sci Technol. 2021. PMID: 34539819 Free PMC article.

10

Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR Studies.

Ma C, Taghour MS, Belal A, Mehany ABM, Mostafa N, Nabeeh A, Eissa IH, Al-Karmalawy AA. Ma C, et al. Front Chem. 2021 Sep 22;9:725135. doi: 10.3389/fchem.2021.725135. eCollection 2021. Front Chem. 2021. PMID: 34631658 Free PMC article.

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