Suppression of AMPK/aak-2 by NRF2/SKN-1 down-regulates autophagy during prolonged oxidative stress.
Kosztelnik M, Kurucz A, Papp D, Jones E, Sigmond T, Barna J, Traka MH, Lorincz T, Szarka A, Banhegyi G, Vellai T, Korcsmaros T, Kapuy O.
Kosztelnik M, et al. Among authors: jones e.
FASEB J. 2019 Feb;33(2):2372-2387. doi: 10.1096/fj.201800565RR. Epub 2018 Oct 2.
FASEB J. 2019.
PMID: 30277819
Free PMC article.
This regulatory connection between NRF2 and AMPK may have an important role in understanding how autophagy is regulated in chronic human morbidities characterized by oxidative stress, such as neurodegenerative diseases, certain cancer types, and in metabolic diseases.-Kosztelnik, …
This regulatory connection between NRF2 and AMPK may have an important role in understanding how autophagy is regulated in chronic human mor …