Novel half-life extended anti-MIF nanobodies protect against endotoxic shock.
Sparkes A, De Baetselier P, Brys L, Cabrito I, Sterckx YG, Schoonooghe S, Muyldermans S, Raes G, Bucala R, Vanlandschoot P, Van Ginderachter JA, Stijlemans B.
Sparkes A, et al.
FASEB J. 2018 Jun;32(6):3411-3422. doi: 10.1096/fj.201701189R. Epub 2018 Jan 25.
FASEB J. 2018.
PMID: 29401625
Free PMC article.
The systemic inflammatory response to infection, which is initiated by activated myeloid cells, plays a key role in the lethal outcome. Macrophage migration inhibitory factor (MIF) is an upstream immunoregulatory mediator, released by myeloid cells, that underlies a …
The systemic inflammatory response to infection, which is initiated by activated myeloid cells, plays a key role in the lethal outcom …