LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes.
Della Valle F, Reddy P, Yamamoto M, Liu P, Saera-Vila A, Bensaddek D, Zhang H, Prieto Martinez J, Abassi L, Celii M, Ocampo A, Nuñez Delicado E, Mangiavacchi A, Aiese Cigliano R, Rodriguez Esteban C, Horvath S, Izpisua Belmonte JC, Orlando V.
Della Valle F, et al. Among authors: saera vila a.
Sci Transl Med. 2022 Aug 10;14(657):eabl6057. doi: 10.1126/scitranslmed.abl6057. Epub 2022 Aug 10.
Sci Transl Med. 2022.
PMID: 35947677