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Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer.
Datta J, Dai X, Bianchi A, De Castro Silva I, Mehra S, Garrido VT, Lamichhane P, Singh SP, Zhou Z, Dosch AR, Messaggio F, Ban Y, Umland O, Hosein PJ, Nagathihalli NS, Merchant NB. Datta J, et al. Among authors: bianchi a. Gastroenterology. 2022 Dec;163(6):1593-1612. doi: 10.1053/j.gastro.2022.07.076. Epub 2022 Aug 7. Gastroenterology. 2022. PMID: 35948109 Free PMC article.
Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer.
Datta J, Bianchi A, De Castro Silva I, Deshpande NU, Cao LL, Mehra S, Singh S, Rafie C, Sun X, Chen X, Dai X, Colaprico A, Sharma P, Dosch AR, Pillai A, Hosein PJ, Nagathihalli NS, Komanduri KV, Wilson JM, Ban Y, Merchant NB. Datta J, et al. Among authors: bianchi a. Oncogene. 2022 Jul;41(28):3640-3654. doi: 10.1038/s41388-022-02368-w. Epub 2022 Jun 14. Oncogene. 2022. PMID: 35701533
Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study.
de Castro Silva I, Bianchi A, Deshpande NU, Sharma P, Mehra S, Garrido VT, Saigh SJ, England J, Hosein PJ, Kwon D, Merchant NB, Datta J. de Castro Silva I, et al. Among authors: bianchi a. Elife. 2022 Sep 15;11:e78921. doi: 10.7554/eLife.78921. Elife. 2022. PMID: 36107485 Free PMC article. Clinical Trial.
Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer.
Bianchi A, De Castro Silva I, Deshpande NU, Singh S, Mehra S, Garrido VT, Guo X, Nivelo LA, Kolonias DS, Saigh SJ, Wieder E, Rafie CI, Dosch AR, Zhou Z, Umland O, Amirian H, Ogobuiro IC, Zhang J, Ban Y, Shiau C, Nagathihalli NS, Montgomery EA, Hwang WL, Brambilla R, Komanduri K, Villarino AV, Toska E, Stanger BZ, Gabrilovich DI, Merchant NB, Datta J. Bianchi A, et al. Cancer Discov. 2023 Jun 2;13(6):1428-1453. doi: 10.1158/2159-8290.CD-22-1046. Cancer Discov. 2023. PMID: 36946782 Free PMC article.
Cell-specific nanoengineering strategy disrupts tolerogenic signaling from myeloid-derived suppressor cells to invigorate antitumor immunity in pancreatic cancer.
Deshpande NU, Bianchi A, Amirian H, De Castro Silva I, Rafie CI, Surnar B, Rajkumar K, Ogobuiro IC, Patel M, Mehra S, Nagathihalli NS, Merchant NB, Dhar S, Datta J. Deshpande NU, et al. Among authors: bianchi a. bioRxiv [Preprint]. 2024 May 30:2024.05.25.594901. doi: 10.1101/2024.05.25.594901. bioRxiv. 2024. PMID: 38854120 Free PMC article. Preprint.
CREB activation drives acinar to ductal reprogramming and promote pancreatic cancer progression in animal models of alcoholic chronic pancreatitis.
Srinivasan S, Mehra S, Bianchi A, Singh S, Dosch AR, Amirian H, Jinka S, Krishnamoorthy V, De Castro Silva I, Box EWI, Garrido V, Totiger TM, Zhou Z, Ban Y, Datta J, VanSaun M, Merchant N, Nagathihalli NS. Srinivasan S, et al. Among authors: bianchi a. bioRxiv [Preprint]. 2024 Jan 5:2024.01.05.574376. doi: 10.1101/2024.01.05.574376. bioRxiv. 2024. PMID: 38903082 Free PMC article. Preprint.
2,457 results