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A phase I/II study of intrathecal trastuzumab in human epidermal growth factor receptor 2-positive (HER2-positive) cancer with leptomeningeal metastases: Safety, efficacy, and cerebrospinal fluid pharmacokinetics.
Kumthekar PU, Avram MJ, Lassman AB, Lin NU, Lee E, Grimm SA, Schwartz M, Bell Burdett KL, Lukas RV, Dixit K, Perron I, Zhang H, Gradishar WJ, Pentsova EI, Jeyapalan S, Groves MD, Melisko M, Raizer JJ. Kumthekar PU, et al. Among authors: perron i. Neuro Oncol. 2023 Mar 14;25(3):557-565. doi: 10.1093/neuonc/noac195. Neuro Oncol. 2023. PMID: 35948282 Free PMC article. Clinical Trial.
Hypothalamic mTORC2 is essential for metabolic health and longevity.
Chellappa K, Brinkman JA, Mukherjee S, Morrison M, Alotaibi MI, Carbajal KA, Alhadeff AL, Perron IJ, Yao R, Purdy CS, DeFelice DM, Wakai MH, Tomasiewicz J, Lin A, Meyer E, Peng Y, Arriola Apelo SI, Puglielli L, Betley JN, Paschos GK, Baur JA, Lamming DW. Chellappa K, et al. Among authors: perron ij. Aging Cell. 2019 Oct;18(5):e13014. doi: 10.1111/acel.13014. Epub 2019 Aug 1. Aging Cell. 2019. PMID: 31373126 Free PMC article.
Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7.
Gerstner JR, Perron IJ, Riedy SM, Yoshikawa T, Kadotani H, Owada Y, Van Dongen HPA, Galante RJ, Dickinson K, Yin JCP, Pack AI, Frank MG. Gerstner JR, et al. Among authors: perron ij. Sci Adv. 2017 Apr 5;3(4):e1602663. doi: 10.1126/sciadv.1602663. eCollection 2017 Apr. Sci Adv. 2017. PMID: 28435883 Free PMC article.
13 results