Sweeny DJ - Search Results

1

Structure activity relationships leading to the identification of the indirect activator of AMPK, R419.

Shaw SJ, Goff DA, Carroll DC, Singh R, Sweeny DJ, Park G, Jenkins Y, Markovtsov V, Sun TQ, Issakani SD, Hitoshi Y, Payan DG. Shaw SJ, et al. Among authors: sweeny dj. Bioorg Med Chem. 2022 Oct 1;71:116951. doi: 10.1016/j.bmc.2022.116951. Epub 2022 Aug 1. Bioorg Med Chem. 2022. PMID: 35973281

2

AMPK activation through mitochondrial regulation results in increased substrate oxidation and improved metabolic parameters in models of diabetes.

Jenkins Y, Sun TQ, Markovtsov V, Foretz M, Li W, Nguyen H, Li Y, Pan A, Uy G, Gross L, Baltgalvis K, Yung SL, Gururaja T, Kinoshita T, Owyang A, Smith IJ, McCaughey K, White K, Godinez G, Alcantara R, Choy C, Ren H, Basile R, Sweeny DJ, Xu X, Issakani SD, Carroll DC, Goff DA, Shaw SJ, Singh R, Boros LG, Laplante MA, Marcotte B, Kohen R, Viollet B, Marette A, Payan DG, Kinsella TM, Hitoshi Y. Jenkins Y, et al. Among authors: sweeny dj. PLoS One. 2013 Dec 5;8(12):e81870. doi: 10.1371/journal.pone.0081870. eCollection 2013. PLoS One. 2013. PMID: 24339975 Free PMC article.

3

Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen.

McLaughlin J, Markovtsov V, Li H, Wong S, Gelman M, Zhu Y, Franci C, Lang D, Pali E, Lasaga J, Low C, Zhao F, Chang B, Gururaja TL, Xu W, Baluom M, Sweeny D, Carroll D, Sran A, Thota S, Parmer M, Romane A, Clemens G, Grossbard E, Qu K, Jenkins Y, Kinoshita T, Taylor V, Holland SJ, Argade A, Singh R, Pine P, Payan DG, Hitoshi Y. McLaughlin J, et al. J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113. doi: 10.1007/s00432-009-0641-1. J Cancer Res Clin Oncol. 2010. PMID: 19609559

4

Metabolism of fostamatinib, the oral methylene phosphate prodrug of the spleen tyrosine kinase inhibitor R406 in humans: contribution of hepatic and gut bacterial processes to the overall biotransformation.

Sweeny DJ, Li W, Clough J, Bhamidipati S, Singh R, Park G, Baluom M, Grossbard E, Lau DT. Sweeny DJ, et al. Drug Metab Dispos. 2010 Jul;38(7):1166-76. doi: 10.1124/dmd.110.032151. Epub 2010 Apr 6. Drug Metab Dispos. 2010. PMID: 20371637

5

Contribution of gut bacteria to the metabolism of the spleen tyrosine kinase (Syk) inhibitor R406 in cynomolgus monkey.

Sweeny DJ, Li W, Grossbard E, Lau DT. Sweeny DJ, et al. Xenobiotica. 2010 Jun;40(6):415-23. doi: 10.3109/00498251003734244. Xenobiotica. 2010. PMID: 20415544

6

Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies.

Martin P, Gillen M, Millson D, Oliver S, Brealey C, Grossbard EB, Baluom M, Lau D, Sweeny D, Mant T, Craven K. Martin P, et al. Drugs R D. 2016 Mar;16(1):81-92. doi: 10.1007/s40268-015-0118-4. Drugs R D. 2016. PMID: 26739683 Free PMC article. Clinical Trial.

7

Effects of Fostamatinib on the Pharmacokinetics of the CYP2C8 Substrate Pioglitazone: Results From In Vitro and Phase 1 Clinical Studies.

Martin P, Gillen M, Millson D, Oliver S, Brealey C, Surry D, Sweeny D, Lau D, Leese P. Martin P, et al. Clin Pharmacol Drug Dev. 2016 May;5(3):170-9. doi: 10.1002/cpdd.243. Epub 2016 Mar 23. Clin Pharmacol Drug Dev. 2016. PMID: 27163495 Clinical Trial.

8

Metabolism of the influenza neuraminidase inhibitor prodrug oseltamivir in the rat.

Sweeny DJ, Lynch G, Bidgood AM, Lew W, Wang KY, Cundy KC. Sweeny DJ, et al. Drug Metab Dispos. 2000 Jul;28(7):737-41. Drug Metab Dispos. 2000. PMID: 10859145

9

Stereoselective glucuronidation of zileuton isomers by human hepatic microsomes.

Sweeny DJ, Nellans HN. Sweeny DJ, et al. Drug Metab Dispos. 1995 Jan;23(1):149-53. Drug Metab Dispos. 1995. PMID: 7720519

10

Distribution, metabolism, and excretion of the anti-angiogenic compound SU5416.

Ye C, Sweeny D, Sukbuntherng J, Zhang Q, Tan W, Wong S, Madan A, Ogilvie B, Parkinson A, Antonian L. Ye C, et al. Toxicol In Vitro. 2006 Mar;20(2):154-62. doi: 10.1016/j.tiv.2005.06.047. Toxicol In Vitro. 2006. PMID: 16321501 Review.

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