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306 results

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Page 1
Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer's disease.
Venkataraman AV, Mansur A, Rizzo G, Bishop C, Lewis Y, Kocagoncu E, Lingford-Hughes A, Huiban M, Passchier J, Rowe JB, Tsukada H, Brooks DJ, Martarello L, Comley RA, Chen L, Schwarz AJ, Hargreaves R, Gunn RN, Rabiner EA, Matthews PM. Venkataraman AV, et al. Among authors: hargreaves r. Sci Transl Med. 2022 Aug 17;14(658):eabk1051. doi: 10.1126/scitranslmed.abk1051. Epub 2022 Aug 17. Sci Transl Med. 2022. PMID: 35976998
Translational PET imaging research.
Hargreaves RJ, Rabiner EA. Hargreaves RJ, et al. Neurobiol Dis. 2014 Jan;61:32-8. doi: 10.1016/j.nbd.2013.08.017. Epub 2013 Sep 17. Neurobiol Dis. 2014. PMID: 24055214 Review.
A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #2: protocol optimization and best practices.
Schwarz AJ, Becerra L, Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Evelhoch J, Hargreaves R, Robertson B, Iyengar S, Tauscher J, Bleakman D, Borsook D. Schwarz AJ, et al. Among authors: hargreaves r. Drug Discov Today. 2011 Aug;16(15-16):671-82. doi: 10.1016/j.drudis.2011.03.011. Epub 2011 Apr 6. Drug Discov Today. 2011. PMID: 21477664 Review.
A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #1: processes and requirements.
Schwarz AJ, Becerra L, Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Evelhoch J, Hargreaves R, Robertson B, Iyengar S, Tauscher J, Bleakman D, Borsook D. Schwarz AJ, et al. Among authors: hargreaves r. Drug Discov Today. 2011 Jul;16(13-14):583-93. doi: 10.1016/j.drudis.2011.05.006. Epub 2011 May 24. Drug Discov Today. 2011. PMID: 21635967 Review.
Modulation of CNS pain circuitry by intravenous and sublingual doses of buprenorphine.
Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Schwarz AJ, Pendse G, Wallin D, Nutile L, Bishop J, George E, Elman I, Sunkaraneni S, Maier G, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Becerra L, Borsook D. Upadhyay J, et al. Among authors: hargreaves r. Neuroimage. 2012 Feb 15;59(4):3762-73. doi: 10.1016/j.neuroimage.2011.11.034. Epub 2011 Nov 18. Neuroimage. 2012. PMID: 22119647
Imaging drugs with and without clinical analgesic efficacy.
Upadhyay J, Anderson J, Schwarz AJ, Coimbra A, Baumgartner R, Pendse G, George E, Nutile L, Wallin D, Bishop J, Neni S, Maier G, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Becerra L, Borsook D. Upadhyay J, et al. Among authors: hargreaves r. Neuropsychopharmacology. 2011 Dec;36(13):2659-73. doi: 10.1038/npp.2011.156. Epub 2011 Aug 17. Neuropsychopharmacology. 2011. PMID: 21849979 Free PMC article. Clinical Trial.
Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain.
Borsook D, Upadhyay J, Klimas M, Schwarz AJ, Coimbra A, Baumgartner R, George E, Potter WZ, Large T, Bleakman D, Evelhoch J, Iyengar S, Becerra L, Hargreaves RJ. Borsook D, et al. Among authors: hargreaves rj. Drug Discov Today. 2012 Sep;17(17-18):964-73. doi: 10.1016/j.drudis.2012.05.004. Epub 2012 May 10. Drug Discov Today. 2012. PMID: 22579743 Review.
Parallel buprenorphine phMRI responses in conscious rodents and healthy human subjects.
Becerra L, Upadhyay J, Chang PC, Bishop J, Anderson J, Baumgartner R, Schwarz AJ, Coimbra A, Wallin D, Nutile L, George E, Maier G, Sunkaraneni S, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Borsook D. Becerra L, et al. Among authors: hargreaves r. J Pharmacol Exp Ther. 2013 Apr;345(1):41-51. doi: 10.1124/jpet.112.201145. Epub 2013 Jan 31. J Pharmacol Exp Ther. 2013. PMID: 23370795 Clinical Trial.
306 results