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Page 1
Antitubercular Activity of Novel 2-(Quinoline-4-yloxy)acetamides with Improved Drug-Like Properties.
Borsoi AF, Alice LM, Sperotto N, Ramos AS, Abbadi BL, Macchi Hopf FS, Silva Dadda AD, Rambo RS, Madeira Silva RB, Paz JD, Pissinate K, Muniz MN, Neves CE, Galina L, González LC, Perelló MA, de Matos Czeczot A, Leyser M, de Oliveira SD, de Araújo Lock G, de Araújo BV, Costa TD, Bizarro CV, Basso LA, Machado P. Borsoi AF, et al. Among authors: muniz mn. ACS Med Chem Lett. 2022 Jul 21;13(8):1337-1344. doi: 10.1021/acsmedchemlett.2c00254. eCollection 2022 Aug 11. ACS Med Chem Lett. 2022. PMID: 35978694 Free PMC article.
Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation.
Paz JD, Denise de Moura Sperotto N, Ramos AS, Pissinate K, da Silva Rodrigues Junior V, Abbadi BL, Borsoi AF, Rambo RS, Corso Minotto AC, da Silva Dadda A, Galina L, Macchi Hopf FS, Muniz MN, Borges Martinelli LK, Roth CD, Madeira Silva RB, Perelló MA, de Matos Czeczot A, Neves CE, Duarte LS, Leyser M, Dias de Oliveira S, Bizarro CV, Machado P, Basso LA. Paz JD, et al. Among authors: muniz mn. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114908. doi: 10.1016/j.ejmech.2022.114908. Epub 2022 Nov 18. Eur J Med Chem. 2023. PMID: 36435016
Crystal structure of dihydroneopterin aldolase from Mycobacterium tuberculosis associated with 8-mercaptoguanine, and development of novel S8-functionalized analogues as inhibitors: Synthesis, enzyme inhibition, in vitro toxicity and antitubercular activity.
Czeczot AM, Muniz MN, Perelló MA, Silva ÉED, Timmers LFSM, Berger A, Gonzalez LC, Arraché Gonçalves G, Moura S, Machado P, Bizarro CV, Basso LA. Czeczot AM, et al. Among authors: muniz mn. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2388207. doi: 10.1080/14756366.2024.2388207. Epub 2024 Aug 14. J Enzyme Inhib Med Chem. 2024. PMID: 39140692 Free PMC article.
Unveiling the Antimycobacterial Potential of Novel 4-Alkoxyquinolines: Insights into Selectivity, Mechanism of Action, and In Vivo Exposure.
da Silva FF, Paz JD, Rambo RS, Gonçalves GA, Muniz MN, de Matos Czeczot A, Perelló MA, Berger A, González LC, Duarte LS, da Silva AB, Ferreira CAS, de Oliveira SD, Moura S, Bizarro CV, Basso LA, Machado P. da Silva FF, et al. Among authors: muniz mn. J Med Chem. 2024 Dec 26;67(24):21781-21794. doi: 10.1021/acs.jmedchem.4c01302. Epub 2024 Dec 4. J Med Chem. 2024. PMID: 39630172 Free PMC article.
Synthesis of isosteric triterpenoid derivatives and antifungal activity.
Innocente A, Casanova BB, Klein F, Lana AD, Pereira D, Muniz MN, Sonnet P, Gosmann G, Fuentefria AM, Gnoatto SC. Innocente A, et al. Among authors: muniz mn. Chem Biol Drug Des. 2014 Mar;83(3):344-9. doi: 10.1111/cbdd.12251. Epub 2014 Feb 1. Chem Biol Drug Des. 2014. PMID: 24138556
A pyrazolyl-thiazole derivative causes antinociception in mice.
Prokopp CR, Rubin MA, Sauzem PD, de Souza AH, Berlese DB, Lourega RV, Muniz MN, Bonacorso HG, Zanatta N, Martins MA, Mello CF. Prokopp CR, et al. Among authors: muniz mn. Braz J Med Biol Res. 2006 Jun;39(6):795-9. doi: 10.1590/s0100-879x2006000600013. Epub 2006 Jun 2. Braz J Med Biol Res. 2006. PMID: 16751986 Free article.