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Distinct Cohorts of Aspergillus fumigatus Transcription Factors Are Required for Epithelial Damage Occurring via Contact- or Soluble Effector-Mediated Mechanisms.
Rahman S, van Rhijn N, Papastamoulis P, Thomson DD, Carter Z, Fortune-Grant R, Rattray M, Bromley MJ, Bignell E. Rahman S, et al. Among authors: bignell e. Front Cell Infect Microbiol. 2022 Jul 28;12:907519. doi: 10.3389/fcimb.2022.907519. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35982778 Free PMC article.
The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis.
Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Muñoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM. Bertuzzi M, et al. PLoS Pathog. 2014 Oct 16;10(10):e1004413. doi: 10.1371/journal.ppat.1004413. eCollection 2014 Oct. PLoS Pathog. 2014. PMID: 25329394 Free PMC article.
A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity.
Johns A, Scharf DH, Gsaller F, Schmidt H, Heinekamp T, Straßburger M, Oliver JD, Birch M, Beckmann N, Dobb KS, Gilsenan J, Rash B, Bignell E, Brakhage AA, Bromley MJ. Johns A, et al. Among authors: bignell e. mBio. 2017 Jul 18;8(4):e01504-16. doi: 10.1128/mBio.01504-16. mBio. 2017. PMID: 28720735 Free PMC article.
Pseudomonas aeruginosa-Derived Volatile Sulfur Compounds Promote Distal Aspergillus fumigatus Growth and a Synergistic Pathogen-Pathogen Interaction That Increases Pathogenicity in Co-infection.
Scott J, Sueiro-Olivares M, Ahmed W, Heddergott C, Zhao C, Thomas R, Bromley M, Latgé JP, Krappmann S, Fowler S, Bignell E, Amich J. Scott J, et al. Among authors: bignell e. Front Microbiol. 2019 Oct 9;10:2311. doi: 10.3389/fmicb.2019.02311. eCollection 2019. Front Microbiol. 2019. PMID: 31649650 Free PMC article.
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus.
Furukawa T, van Rhijn N, Fraczek M, Gsaller F, Davies E, Carr P, Gago S, Fortune-Grant R, Rahman S, Gilsenan JM, Houlder E, Kowalski CH, Raj S, Paul S, Cook P, Parker JE, Kelly S, Cramer RA, Latgé JP, Moye-Rowley S, Bignell E, Bowyer P, Bromley MJ. Furukawa T, et al. Among authors: bignell e. Nat Commun. 2020 Jan 22;11(1):427. doi: 10.1038/s41467-019-14191-1. Nat Commun. 2020. PMID: 31969561 Free PMC article.
80 results