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PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120.
Fazio G, Bresolin S, Silvestri D, Quadri M, Saitta C, Vendramini E, Buldini B, Palmi C, Bardini M, Grioni A, Rigamonti S, Galbiati M, Mecca S, Savino AM, Peloso A, Tu JW, Bhatia S, Borkhardt A, Micalizzi C, Lo Nigro L, Locatelli F, Conter V, Rizzari C, Valsecchi MG, Te Kronnie G, Biondi A, Cazzaniga G. Fazio G, et al. EBioMedicine. 2022 Sep;83:104224. doi: 10.1016/j.ebiom.2022.104224. Epub 2022 Aug 16. EBioMedicine. 2022. PMID: 35985167 Free PMC article.
TEL/ARG induces cytoskeletal abnormalities in 293T cells.
Palmi C, Fazio G, Cassetti A, Aloisi A, Villa A, Biondi A, Cazzaniga G. Palmi C, et al. Among authors: fazio g. Cancer Lett. 2006 Sep 8;241(1):79-86. doi: 10.1016/j.canlet.2005.10.017. Epub 2005 Nov 28. Cancer Lett. 2006. PMID: 16310306
DNA copy-number abnormalities do not occur in infant ALL with t(4;11)/MLL-AF4.
Bardini M, Spinelli R, Bungaro S, Mangano E, Corral L, Cifola I, Fazio G, Giordan M, Basso G, De Rossi G, Biondi A, Battaglia C, Cazzaniga G. Bardini M, et al. Among authors: fazio g. Leukemia. 2010 Jan;24(1):169-76. doi: 10.1038/leu.2009.203. Epub 2009 Nov 12. Leukemia. 2010. PMID: 19907438
Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia.
Palmi C, Vendramini E, Silvestri D, Longinotti G, Frison D, Cario G, Shochat C, Stanulla M, Rossi V, Di Meglio AM, Villa T, Giarin E, Fazio G, Leszl A, Schrappe M, Basso G, Biondi A, Izraeli S, Conter V, Valsecchi MG, Cazzaniga G, Te Kronnie G. Palmi C, et al. Among authors: fazio g. Leukemia. 2012 Oct;26(10):2245-53. doi: 10.1038/leu.2012.101. Epub 2012 Apr 9. Leukemia. 2012. PMID: 22484421
351 results