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Page 1
PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120.
Fazio G, Bresolin S, Silvestri D, Quadri M, Saitta C, Vendramini E, Buldini B, Palmi C, Bardini M, Grioni A, Rigamonti S, Galbiati M, Mecca S, Savino AM, Peloso A, Tu JW, Bhatia S, Borkhardt A, Micalizzi C, Lo Nigro L, Locatelli F, Conter V, Rizzari C, Valsecchi MG, Te Kronnie G, Biondi A, Cazzaniga G. Fazio G, et al. Among authors: savino am. EBioMedicine. 2022 Sep;83:104224. doi: 10.1016/j.ebiom.2022.104224. Epub 2022 Aug 16. EBioMedicine. 2022. PMID: 35985167 Free PMC article.
Impact of IKZF1 deletions on IKZF1 expression and outcome in Philadelphia chromosome negative childhood BCP-ALL. Reply to "incidence and biological significance of IKZF1/Ikaros gene deletions in pediatric Philadelphia chromosome negative and Philadelphia chromosome positive B-cell precursor acute lymphoblastic leukemia".
Palmi C, Lana T, Silvestri D, Savino A, Kronnie GT, Conter V, Basso G, Biondi A, Valsecchi MG, Cazzaniga G. Palmi C, et al. Haematologica. 2013 Dec;98(12):e164-5. doi: 10.3324/haematol.2013.099077. Haematologica. 2013. PMID: 24323991 Free PMC article. No abstract available.
Cytoskeletal regulatory gene expression and migratory properties of B-cell progenitors are affected by the ETV6-RUNX1 rearrangement.
Palmi C, Fazio G, Savino AM, Procter J, Howell L, Cazzaniga V, Vieri M, Longinotti G, Brunati I, Andrè V, Della Mina P, Villa A, Greaves M, Biondi A, D'Amico G, Ford A, Cazzaniga G. Palmi C, et al. Among authors: savino am. Mol Cancer Res. 2014 Dec;12(12):1796-806. doi: 10.1158/1541-7786.MCR-14-0056-T. Epub 2014 Jul 24. Mol Cancer Res. 2014. PMID: 25061103
Fine tuning of surface CRLF2 expression and its associated signaling profile in childhood B-cell precursor acute lymphoblastic leukemia.
Bugarin C, Sarno J, Palmi C, Savino AM, te Kronnie G, Dworzak M, Shumich A, Buldini B, Maglia O, Sala S, Bronzini I, Bourquin JP, Mejstrikova E, Hrusak O, Luria D, Basso G, Izraeli S, Biondi A, Cazzaniga G, Gaipa G; I-BFM study group. Bugarin C, et al. Among authors: savino am. Haematologica. 2015 Jun;100(6):e229-32. doi: 10.3324/haematol.2014.114447. Epub 2015 Apr 10. Haematologica. 2015. PMID: 25862705 Free PMC article. Clinical Trial. No abstract available.
CRLF2 over-expression is a poor prognostic marker in children with high risk T-cell acute lymphoblastic leukemia.
Palmi C, Savino AM, Silvestri D, Bronzini I, Cario G, Paganin M, Buldini B, Galbiati M, Muckenthaler MU, Bugarin C, Della Mina P, Nagel S, Barisone E, Casale F, Locatelli F, Lo Nigro L, Micalizzi C, Parasole R, Pession A, Putti MC, Santoro N, Testi AM, Ziino O, Kulozik AE, Zimmermann M, Schrappe M, Villa A, Gaipa G, Basso G, Biondi A, Valsecchi MG, Stanulla M, Conter V, Te Kronnie G, Cazzaniga G. Palmi C, et al. Among authors: savino am. Oncotarget. 2016 Sep 13;7(37):59260-59272. doi: 10.18632/oncotarget.10610. Oncotarget. 2016. PMID: 27449287 Free PMC article.
Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome.
Schwartzman O, Savino AM, Gombert M, Palmi C, Cario G, Schrappe M, Eckert C, von Stackelberg A, Huang JY, Hameiri-Grossman M, Avigad S, Te Kronnie G, Geron I, Birger Y, Rein A, Zarfati G, Fischer U, Mukamel Z, Stanulla M, Biondi A, Cazzaniga G, Vetere A, Wagner BK, Chen Z, Chen SJ, Tanay A, Borkhardt A, Izraeli S. Schwartzman O, et al. Among authors: savino am. Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4030-E4039. doi: 10.1073/pnas.1702489114. Epub 2017 May 1. Proc Natl Acad Sci U S A. 2017. PMID: 28461505 Free PMC article.
Antileukemic Efficacy of BET Inhibitor in a Preclinical Mouse Model of MLL-AF4+ Infant ALL.
Bardini M, Trentin L, Rizzo F, Vieri M, Savino AM, Garrido Castro P, Fazio G, Van Roon EHJ, Kerstjens M, Smithers N, Prinjha RK, Te Kronnie G, Basso G, Stam RW, Pieters R, Biondi A, Cazzaniga G. Bardini M, et al. Among authors: savino am. Mol Cancer Ther. 2018 Aug;17(8):1705-1716. doi: 10.1158/1535-7163.MCT-17-1123. Epub 2018 May 10. Mol Cancer Ther. 2018. PMID: 29748211
SRC/ABL inhibition disrupts CRLF2-driven signaling to induce cell death in B-cell acute lymphoblastic leukemia.
Sarno J, Savino AM, Buracchi C, Palmi C, Pinto S, Bugarin C, Jager A, Bresolin S, Barber RC, Silvestri D, Israeli S, Dyer MJS, Cazzaniga G, Nolan GP, Biondi A, Davis KL, Gaipa G. Sarno J, et al. Among authors: savino am. Oncotarget. 2018 May 1;9(33):22872-22885. doi: 10.18632/oncotarget.25089. eCollection 2018 May 1. Oncotarget. 2018. PMID: 29796158 Free PMC article.
Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment is dependent on Stearoyl CoA desaturase.
Savino AM, Fernandes SI, Olivares O, Zemlyansky A, Cousins A, Markert EK, Barel S, Geron I, Frishman L, Birger Y, Eckert C, Tumanov S, MacKay G, Kamphorst JJ, Herzyk P, Fernández-García J, Abramovich I, Mor I, Bardini M, Barin E, Janaki-Raman S, Cross JR, Kharas MG, Gottlieb E, Izraeli S, Halsey C. Savino AM, et al. Nat Cancer. 2020 Oct;1(10):998-1009. doi: 10.1038/s43018-020-00115-2. Epub 2020 Sep 28. Nat Cancer. 2020. PMID: 33479702 Free PMC article.
28 results