Lu HR - Search Results

1

Is the forming of neuronal network activity in human-induced pluripotent stem cells important for the detection of drug-induced seizure risks?

Kreir M, Floren W, Policarpo R, De Bondt A, Van den Wyngaert I, Teisman A, Gallacher DJ, Lu HR. Kreir M, et al. Among authors: lu hr. Eur J Pharmacol. 2022 Sep 15;931:175189. doi: 10.1016/j.ejphar.2022.175189. Epub 2022 Aug 18. Eur J Pharmacol. 2022. PMID: 35987255

2

Inhibition of Na+/Ca2+ overload with R 56,865 protects against cardiac arrhythmias elicited by ouabain in vivo in guinea-pigs.

Lu HR, Remeysen P, De Clerck F. Lu HR, et al. Eur J Pharmacol. 1993 Apr 22;235(1):89-93. doi: 10.1016/0014-2999(93)90824-2. Eur J Pharmacol. 1993. PMID: 8519283

3

Drug-induced long QT in isolated rabbit Purkinje fibers: importance of action potential duration, triangulation and early afterdepolarizations.

Lu HR, Vlaminckx E, Van Ammel K, De Clerck F. Lu HR, et al. Eur J Pharmacol. 2002 Oct 4;452(2):183-92. doi: 10.1016/s0014-2999(02)02246-x. Eur J Pharmacol. 2002. PMID: 12354568

4

Both beta-adrenergic receptor stimulation and cardiac tissue type have important roles in elucidating the functional effects of I(Ks) channel blockers in vitro.

Lu HR, Vlaminckx E, Van De Water A, Gallacher DJ. Lu HR, et al. J Pharmacol Toxicol Methods. 2005 Mar-Apr;51(2):81-90. doi: 10.1016/j.vascn.2004.10.004. J Pharmacol Toxicol Methods. 2005. PMID: 15767201

5

A new method to calculate the beat-to-beat instability of QT duration in drug-induced long QT in anesthetized dogs.

van der Linde H, Van de Water A, Loots W, Van Deuren B, Lu HR, Van Ammel K, Peeters M, Gallacher DJ. van der Linde H, et al. Among authors: lu hr. J Pharmacol Toxicol Methods. 2005 Jul-Aug;52(1):168-77. doi: 10.1016/j.vascn.2005.03.005. J Pharmacol Toxicol Methods. 2005. PMID: 15935709

6

Choice of cardiac tissue plays an important role in the evaluation of drug-induced prolongation of the QT interval in vitro in rabbit.

Lu HR, Vlaminckx E, Teisman A, Gallacher DJ. Lu HR, et al. J Pharmacol Toxicol Methods. 2005 Jul-Aug;52(1):90-105. doi: 10.1016/j.vascn.2005.04.007. J Pharmacol Toxicol Methods. 2005. PMID: 15978848

7

Calmodulin antagonist W-7 prevents sparfloxacin-induced early afterdepolarizations (EADs) in isolated rabbit purkinje fibers: importance of beat-to-beat instability of the repolarization.

Lu HR, Vlaminckx E, Van de Water A, Gallacher DJ. Lu HR, et al. J Cardiovasc Electrophysiol. 2006 Apr;17(4):415-22. doi: 10.1111/j.1540-8167.2006.00420.x. J Cardiovasc Electrophysiol. 2006. PMID: 16643366

8

In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation.

Lu HR, Vlaminckx E, Van de Water A, Rohrbacher J, Hermans A, Gallacher DJ. Lu HR, et al. Eur J Pharmacol. 2006 Dec 28;553(1-3):229-39. doi: 10.1016/j.ejphar.2006.09.035. Epub 2006 Sep 23. Eur J Pharmacol. 2006. Corrected and republished in: Eur J Pharmacol. 2007 Dec 22;577(1-3):222-32. doi: 10.1016/j.ejphar.2007.07.070 PMID: 17054943 Corrected and republished.

9

In vivo mechanisms precipitating torsades de pointes in a canine model of drug-induced long-QT1 syndrome.

Gallacher DJ, Van de Water A, van der Linde H, Hermans AN, Lu HR, Towart R, Volders PG. Gallacher DJ, et al. Among authors: lu hr. Cardiovasc Res. 2007 Nov 1;76(2):247-56. doi: 10.1016/j.cardiores.2007.06.019. Epub 2007 Jun 29. Cardiovasc Res. 2007. PMID: 17669388

10

Choice of cardiac tissue in vitro plays an important role in assessing the risk of drug-induced cardiac arrhythmias in human: beyond QT prolongation.

Lu HR, Vlaminckx E, Gallacher DJ. Lu HR, et al. J Pharmacol Toxicol Methods. 2008 Jan-Feb;57(1):1-8. doi: 10.1016/j.vascn.2007.06.005. Epub 2007 Jul 17. J Pharmacol Toxicol Methods. 2008. PMID: 17964190

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