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302 results

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AAV-mediated gene therapy improving mitochondrial function provides benefit in age-related macular degeneration models.
Millington-Ward S, Chadderton N, Finnegan LK, Post IJM, Carrigan M, Gardiner T, Peixoto E, Maloney D, Humphries MM, Stitt A, Léveillard T, Humphries P, Kenna PF, Palfi A, Farrar GJ. Millington-Ward S, et al. Among authors: humphries p, humphries mm. Clin Transl Med. 2022 Aug;12(8):e952. doi: 10.1002/ctm2.952. Clin Transl Med. 2022. PMID: 35988157 Free PMC article. No abstract available.
Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10).
Tam LC, Kiang AS, Kennan A, Kenna PF, Chadderton N, Ader M, Palfi A, Aherne A, Ayuso C, Campbell M, Reynolds A, McKee A, Humphries MM, Farrar GJ, Humphries P. Tam LC, et al. Among authors: humphries p, humphries mm. Hum Mol Genet. 2008 Jul 15;17(14):2084-100. doi: 10.1093/hmg/ddn107. Epub 2008 Apr 1. Hum Mol Genet. 2008. PMID: 18385099
Protection of photoreceptors in a mouse model of RP10.
Tam LC, Kiang AS, Chadderton N, Kenna PF, Campbell M, Humphries MM, Farrar GJ, Humphries P. Tam LC, et al. Among authors: humphries p, humphries mm. Adv Exp Med Biol. 2010;664:559-65. doi: 10.1007/978-1-4419-1399-9_64. Adv Exp Med Biol. 2010. PMID: 20238059
Toward an elucidation of the molecular genetics of inherited retinal degenerations.
Farrar GJ, Carrigan M, Dockery A, Millington-Ward S, Palfi A, Chadderton N, Humphries M, Kiang AS, Kenna PF, Humphries P. Farrar GJ, et al. Among authors: humphries m, humphries p. Hum Mol Genet. 2017 Aug 1;26(R1):R2-R11. doi: 10.1093/hmg/ddx185. Hum Mol Genet. 2017. PMID: 28510639 Free PMC article. Review.
AAV-PHP.eB transduces both the inner and outer retina with high efficacy in mice.
Palfi A, Chadderton N, Millington-Ward S, Post I, Humphries P, Kenna PF, Farrar GJ. Palfi A, et al. Among authors: humphries p. Mol Ther Methods Clin Dev. 2022 Mar 28;25:236-249. doi: 10.1016/j.omtm.2022.03.016. eCollection 2022 Jun 9. Mol Ther Methods Clin Dev. 2022. PMID: 35474956 Free PMC article.
A transgenic mouse model for gene therapy of rhodopsin-linked Retinitis Pigmentosa.
O'Reilly M, Millington-Ward S, Palfi A, Chadderton N, Cronin T, McNally N, Humphries MM, Humphries P, Kenna PF, Farrar GJ. O'Reilly M, et al. Among authors: humphries p, humphries mm. Vision Res. 2008 Feb;48(3):386-91. doi: 10.1016/j.visres.2007.08.014. Epub 2007 Oct 24. Vision Res. 2008. PMID: 17920651 Free article.
302 results