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332 results

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Antifungal Potential of Synthetic Peptides against Cryptococcus neoformans: Mechanism of Action Studies Reveal Synthetic Peptides Induce Membrane-Pore Formation, DNA Degradation, and Apoptosis.
Aguiar TKB, Neto NAS, Freitas CDT, Silva AFB, Bezerra LP, Malveira EA, Branco LAC, Mesquita FP, Goldman GH, Alencar LMR, Oliveira JTA, Santos-Oliveira R, Souza PFN. Aguiar TKB, et al. Among authors: goldman gh. Pharmaceutics. 2022 Aug 12;14(8):1678. doi: 10.3390/pharmaceutics14081678. Pharmaceutics. 2022. PMID: 36015304 Free PMC article.
A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi.
Dos Reis TF, de Castro PA, Bastos RW, Pinzan CF, Souza PFN, Ackloo S, Hossain MA, Drewry DH, Alkhazraji S, Ibrahim AS, Jo H, Lightfoot JD, Adams EM, Fuller KK, deGrado WF, Goldman GH. Dos Reis TF, et al. Among authors: goldman gh. Nat Commun. 2023 Apr 12;14(1):2052. doi: 10.1038/s41467-023-37573-y. Nat Commun. 2023. PMID: 37045836 Free PMC article.
Potential of Gallium as an Antifungal Agent.
Bastos RW, Rossato L, Valero C, Lagrou K, Colombo AL, Goldman GH. Bastos RW, et al. Among authors: goldman gh. Front Cell Infect Microbiol. 2019 Dec 11;9:414. doi: 10.3389/fcimb.2019.00414. eCollection 2019. Front Cell Infect Microbiol. 2019. PMID: 31921699 Free PMC article.
Brilacidin, a novel antifungal agent against Cryptococcus neoformans.
Diehl C, Pinzan CF, de Castro PA, Delbaje E, García Carnero LC, Sánchez-León E, Bhalla K, Kronstad JW, Kim D-g, Doering TL, Alkhazraji S, Mishra NN, Ibrahim AS, Yoshimura M, Vega Isuhuaylas LA, Pham LTK, Yashiroda Y, Boone C, Dos Reis TF, Goldman GH. Diehl C, et al. Among authors: goldman gh. mBio. 2024 Jul 17;15(7):e0103124. doi: 10.1128/mbio.01031-24. Epub 2024 Jun 25. mBio. 2024. PMID: 38916308 Free PMC article.
Sirtuin E deacetylase is required for full virulence of Aspergillus fumigatus.
Wassano NS, da Silva GB, Reis AH, A Gerhardt J, Antoniel EP, Akiyama D, Rezende CP, Neves LX, Vasconcelos EJR, de Figueiredo FL, Almeida F, de Castro PA, Pinzan CF, Goldman GH, Paes Leme AF, Fill TP, Moretti NS, Damasio A. Wassano NS, et al. Among authors: goldman gh. Commun Biol. 2024 Jun 8;7(1):704. doi: 10.1038/s42003-024-06383-3. Commun Biol. 2024. PMID: 38851817 Free PMC article.
Screening of Chemical Libraries for New Antifungal Drugs against Aspergillus fumigatus Reveals Sphingolipids Are Involved in the Mechanism of Action of Miltefosine.
Dos Reis TF, Horta MAC, Colabardini AC, Fernandes CM, Silva LP, Bastos RW, Fonseca MVL, Wang F, Martins C, Rodrigues ML, Silva Pereira C, Del Poeta M, Wong KH, Goldman GH. Dos Reis TF, et al. Among authors: goldman gh. mBio. 2021 Aug 31;12(4):e0145821. doi: 10.1128/mBio.01458-21. Epub 2021 Aug 10. mBio. 2021. PMID: 34372704 Free PMC article.
332 results