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Gut immune cells-A novel therapeutical target for cardiovascular disease?
Ganesh N, van der Vorst EPC, Spiesshöfer J, He S, Burgmaier M, Findeisen H, Lehrke M, Swirski FK, Marx N, Kahles F. Ganesh N, et al. Among authors: kahles f. Front Cardiovasc Med. 2022 Aug 15;9:943214. doi: 10.3389/fcvm.2022.943214. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 36046186 Free PMC article. Review.
Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress, and extracellular vesicle release in vascular smooth muscle cells.
Petsophonsakul P, Burgmaier M, Willems B, Heeneman S, Stadler N, Gremse F, Reith S, Burgmaier K, Kahles F, Marx N, Natour E, Bidar E, Jacobs M, Mees B, Reutelingsperger C, Furmanik M, Schurgers L. Petsophonsakul P, et al. Among authors: kahles f. Cardiovasc Res. 2022 Jul 20;118(9):2196-2210. doi: 10.1093/cvr/cvab244. Cardiovasc Res. 2022. PMID: 34273166 Free PMC article.
Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.
He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK. He S, et al. Among authors: kahles f. Nature. 2019 Feb;566(7742):115-119. doi: 10.1038/s41586-018-0849-9. Epub 2019 Jan 30. Nature. 2019. PMID: 30700910 Free PMC article.
The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE-/- mice by blocking monocyte/macrophage activation.
Kahles F, Liberman A, Halim C, Rau M, Möllmann J, Mertens RW, Rückbeil M, Diepolder I, Walla B, Diebold S, Burgmaier M, Lebherz C, Marx N, Lehrke M. Kahles F, et al. Mol Metab. 2018 Aug;14:150-157. doi: 10.1016/j.molmet.2018.05.014. Epub 2018 May 23. Mol Metab. 2018. PMID: 29884547 Free PMC article.
54 results