Parson MAH - Search Results

1

A previously uncharacterized O-glycopeptidase from Akkermansia muciniphila requires the Tn-antigen for cleavage of the peptide bond.

Medley BJ, Leclaire L, Thompson N, Mahoney KE, Pluvinage B, Parson MAH, Burke JE, Malaker S, Wakarchuk W, Boraston AB. Medley BJ, et al. Among authors: parson mah. J Biol Chem. 2022 Oct;298(10):102439. doi: 10.1016/j.jbc.2022.102439. Epub 2022 Aug 30. J Biol Chem. 2022. PMID: 36049519 Free PMC article.

2

Biochemical Insight into Novel Rab-GEF Activity of the Mammalian TRAPPIII Complex.

Harris NJ, Jenkins ML, Dalwadi U, Fleming KD, Nam SE, Parson MAH, Yip CK, Burke JE. Harris NJ, et al. Among authors: parson mah. J Mol Biol. 2021 Sep 3;433(18):167145. doi: 10.1016/j.jmb.2021.167145. Epub 2021 Jul 3. J Mol Biol. 2021. PMID: 34229011

3

Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane.

Ulengin-Talkish I, Parson MAH, Jenkins ML, Roy J, Shih AZL, St-Denis N, Gulyas G, Balla T, Gingras AC, Várnai P, Conibear E, Burke JE, Cyert MS. Ulengin-Talkish I, et al. Among authors: parson mah. Nat Commun. 2021 Oct 18;12(1):6064. doi: 10.1038/s41467-021-26326-4. Nat Commun. 2021. PMID: 34663815 Free PMC article.

4

Investigating how intrinsically disordered regions contribute to protein function using HDX-MS.

Parson MAH, Jenkins ML, Burke JE. Parson MAH, et al. Biochem Soc Trans. 2022 Dec 16;50(6):1607-1617. doi: 10.1042/BST20220206. Biochem Soc Trans. 2022. PMID: 36454645 Review.

5

Molecular basis for the recruitment of the Rab effector protein WDR44 by the GTPase Rab11.

Thibodeau MC, Harris NJ, Jenkins ML, Parson MAH, Evans JT, Scott MK, Shaw AL, Pokorný D, Leonard TA, Burke JE. Thibodeau MC, et al. Among authors: parson mah. J Biol Chem. 2023 Jan;299(1):102764. doi: 10.1016/j.jbc.2022.102764. Epub 2022 Dec 1. J Biol Chem. 2023. PMID: 36463963 Free PMC article.

6

Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus.

Jenkins ML, Ranga-Prasad H, Parson MAH, Harris NJ, Rathinaswamy MK, Burke JE. Jenkins ML, et al. Among authors: parson mah. Nat Commun. 2023 Jan 12;14(1):181. doi: 10.1038/s41467-023-35789-6. Nat Commun. 2023. PMID: 36635288 Free PMC article.

7

PKD autoinhibition in trans regulates activation loop autophosphorylation in cis.

Reinhardt R, Hirzel K, Link G, Eisler SA, Hägele T, Parson MAH, Burke JE, Hausser A, Leonard TA. Reinhardt R, et al. Among authors: parson mah. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2212909120. doi: 10.1073/pnas.2212909120. Epub 2023 Feb 6. Proc Natl Acad Sci U S A. 2023. PMID: 36745811 Free PMC article.

8

ATP-competitive and allosteric inhibitors induce differential conformational changes at the autoinhibitory interface of Akt1.

Shaw AL, Parson MAH, Truebestein L, Jenkins ML, Leonard TA, Burke JE. Shaw AL, et al. Among authors: parson mah. Structure. 2023 Mar 2;31(3):343-354.e3. doi: 10.1016/j.str.2023.01.007. Epub 2023 Feb 8. Structure. 2023. PMID: 36758543 Free article.

9

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain.

Harris NJ, Jenkins ML, Nam SE, Rathinaswamy MK, Parson MA, Ranga-Prasad H, Dalwadi U, Moeller BE, Sheekey E, Hansen SD, Yip CK, Burke JE. Harris NJ, et al. bioRxiv [Preprint]. 2023 May 23:2023.04.12.536585. doi: 10.1101/2023.04.12.536585. bioRxiv. 2023. Update in: Elife. 2023 Jul 07;12:RP88058. doi: 10.7554/eLife.88058 PMID: 37090531 Free PMC article. Updated. Preprint.

10

Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain.

Harris NJ, Jenkins ML, Nam SE, Rathinaswamy MK, Parson MAH, Ranga-Prasad H, Dalwadi U, Moeller BE, Sheeky E, Hansen SD, Yip CK, Burke JE. Harris NJ, et al. Among authors: parson mah. Elife. 2023 Jul 7;12:RP88058. doi: 10.7554/eLife.88058. Elife. 2023. PMID: 37417733 Free PMC article.

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