Umbaugh DS - Search Results

1

Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts.

Umbaugh DS, Soder RP, Nguyen NT, Adelusi O, Robarts DR, Woolbright B, Duan L, Abhyankar S, Dawn B, Apte U, Jaeschke H, Ramachandran A. Umbaugh DS, et al. Arch Toxicol. 2022 Dec;96(12):3315-3329. doi: 10.1007/s00204-022-03372-5. Epub 2022 Sep 4. Arch Toxicol. 2022. PMID: 36057886 Free PMC article.

2

Novel Therapeutic Approaches Against Acetaminophen-induced Liver Injury and Acute Liver Failure.

Jaeschke H, Akakpo JY, Umbaugh DS, Ramachandran A. Jaeschke H, et al. Among authors: umbaugh ds. Toxicol Sci. 2020 Apr 1;174(2):159-167. doi: 10.1093/toxsci/kfaa002. Toxicol Sci. 2020. PMID: 31926003 Free PMC article. Review.

3

Biomarkers of drug-induced liver injury: a mechanistic perspective through acetaminophen hepatotoxicity.

Umbaugh DS, Jaeschke H. Umbaugh DS, et al. Expert Rev Gastroenterol Hepatol. 2021 Apr;15(4):363-375. doi: 10.1080/17474124.2021.1857238. Epub 2020 Dec 9. Expert Rev Gastroenterol Hepatol. 2021. PMID: 33242385 Free PMC article. Review.

4

Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.

Nguyen NT, Du K, Akakpo JY, Umbaugh DS, Jaeschke H, Ramachandran A. Nguyen NT, et al. Among authors: umbaugh ds. Toxicol Lett. 2021 Mar 1;338:21-31. doi: 10.1016/j.toxlet.2020.12.005. Epub 2020 Dec 5. Toxicol Lett. 2021. PMID: 33290831 Free PMC article.

5

Mitochondrial Membrane Potential Drives Early Change in Mitochondrial Morphology After Acetaminophen Exposure.

Umbaugh DS, Nguyen NT, Jaeschke H, Ramachandran A. Umbaugh DS, et al. Toxicol Sci. 2021 Feb 26;180(1):186-195. doi: 10.1093/toxsci/kfaa188. Toxicol Sci. 2021. PMID: 33432343 Free PMC article.

6

Spatial Reconstruction of the Early Hepatic Transcriptomic Landscape After an Acetaminophen Overdose Using Single-Cell RNA-Sequencing.

Umbaugh DS, Ramachandran A, Jaeschke H. Umbaugh DS, et al. Toxicol Sci. 2021 Aug 3;182(2):327-345. doi: 10.1093/toxsci/kfab052. Toxicol Sci. 2021. PMID: 33983442 Free PMC article.

7

Extracellular vesicles: Roles and applications in drug-induced liver injury.

Umbaugh DS, Jaeschke H. Umbaugh DS, et al. Adv Clin Chem. 2021;102:63-125. doi: 10.1016/bs.acc.2020.08.010. Epub 2020 Oct 1. Adv Clin Chem. 2021. PMID: 34044913 Free PMC article. Review.

8

Mitochondrial Dynamics in Drug-Induced Liver Injury.

Ramachandran A, Umbaugh DS, Jaeschke H. Ramachandran A, et al. Among authors: umbaugh ds. Livers. 2021;1(3):102-115. doi: 10.3390/livers1030010. Epub 2021 Jun 23. Livers. 2021. PMID: 34485975 Free PMC article.

9

Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice.

Nguyen NT, Umbaugh DS, Sanchez-Guerrero G, Ramachandran A, Jaeschke H. Nguyen NT, et al. Among authors: umbaugh ds. Arch Toxicol. 2022 Jan;96(1):305-320. doi: 10.1007/s00204-021-03183-0. Epub 2021 Nov 1. Arch Toxicol. 2022. PMID: 34724096 Free PMC article.

10

Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls.

Jaeschke H, Adelusi OB, Akakpo JY, Nguyen NT, Sanchez-Guerrero G, Umbaugh DS, Ding WX, Ramachandran A. Jaeschke H, et al. Among authors: umbaugh ds. Acta Pharm Sin B. 2021 Dec;11(12):3740-3755. doi: 10.1016/j.apsb.2021.09.023. Epub 2021 Sep 30. Acta Pharm Sin B. 2021. PMID: 35024303 Free PMC article. Review.

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