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Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium.
Ueoka R, Sondermann P, Leopold-Messer S, Liu Y, Suo R, Bhushan A, Vadakumchery L, Greczmiel U, Yashiroda Y, Kimura H, Nishimura S, Hoshikawa Y, Yoshida M, Oxenius A, Matsunaga S, Williamson RT, Carreira EM, Piel J. Ueoka R, et al. Among authors: kimura h. Nat Chem. 2022 Oct;14(10):1193-1201. doi: 10.1038/s41557-022-01020-0. Epub 2022 Sep 5. Nat Chem. 2022. PMID: 36064972 Free PMC article.
Jerveratrum-Type Steroidal Alkaloids Inhibit β-1,6-Glucan Biosynthesis in Fungal Cell Walls.
Kubo K, Itto-Nakama K, Ohnuki S, Yashiroda Y, Li SC, Kimura H, Kawamura Y, Shimamoto Y, Tominaga KI, Yamanaka D, Adachi Y, Takashima S, Noda Y, Boone C, Ohya Y. Kubo K, et al. Among authors: kimura h. Microbiol Spectr. 2022 Feb 23;10(1):e0087321. doi: 10.1128/spectrum.00873-21. Epub 2022 Jan 12. Microbiol Spectr. 2022. PMID: 35019680 Free PMC article.
Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity.
Iyer KR, Li SC, Revie NM, Lou JW, Duncan D, Fallah S, Sanchez H, Skulska I, Ušaj MM, Safizadeh H, Larsen B, Wong C, Aman A, Kiyota T, Yoshimura M, Kimura H, Hirano H, Yoshida M, Osada H, Gingras AC, Andes DR, Shapiro RS, Robbins N, Mazhab-Jafari MT, Whitesell L, Yashiroda Y, Boone C, Cowen LE. Iyer KR, et al. Among authors: kimura h. Cell Chem Biol. 2023 Jul 20;30(7):795-810.e8. doi: 10.1016/j.chembiol.2023.06.005. Epub 2023 Jun 26. Cell Chem Biol. 2023. PMID: 37369212 Free PMC article.
Exposed Hsp70-binding site impacts yeast Sup35 prion disaggregation and propagation.
Shen CH, Komi Y, Nakagawa Y, Kamatari YO, Nomura T, Kimura H, Shida T, Burke J, Tamai S, Ishida Y, Tanaka M. Shen CH, et al. Among authors: kimura h. Proc Natl Acad Sci U S A. 2024 Dec 17;121(51):e2318162121. doi: 10.1073/pnas.2318162121. Epub 2024 Dec 10. Proc Natl Acad Sci U S A. 2024. PMID: 39656207 Free PMC article.
The Combination of Tumor-targeting Salmonella typhimurium A1-R Plus the Autophagy-inhibitor Chloroquine Synergistically Eradicates HT1080 Fibrosarcoma Cells In Vitro and In Vivo.
Morinaga S, Zhao M, Mizuta K, Kang BM, Bouvet M, Yamamoto N, Hayashi K, Kimura H, Miwa S, Igarashi K, Higuchi T, Tsuchiya H, Demura S, Hoffman RM. Morinaga S, et al. Among authors: kimura h. In Vivo. 2025 Jan-Feb;39(1):102-109. doi: 10.21873/invivo.13807. In Vivo. 2025. PMID: 39740880
5,914 results