He M - Search Results

1

Optimization of the Prodrug Moiety of Remdesivir to Improve Lung Exposure/Selectivity and Enhance Anti-SARS-CoV-2 Activity.

Hu H, Mady Traore MD, Li R, Yuan H, He M, Wen B, Gao W, Jonsson CB, Fitzpatrick EA, Sun D. Hu H, et al. Among authors: he m. J Med Chem. 2022 Sep 22;65(18):12044-12054. doi: 10.1021/acs.jmedchem.2c00758. Epub 2022 Sep 7. J Med Chem. 2022. PMID: 36070561

2

Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL).

Borkin D, Pollock J, Kempinska K, Purohit T, Li X, Wen B, Zhao T, Miao H, Shukla S, He M, Sun D, Cierpicki T, Grembecka J. Borkin D, et al. Among authors: he m. J Med Chem. 2016 Feb 11;59(3):892-913. doi: 10.1021/acs.jmedchem.5b01305. Epub 2016 Jan 25. J Med Chem. 2016. PMID: 26744767 Free PMC article.

3

Anti-infective Activity of 2-Cyano-3-Acrylamide Inhibitors with Improved Drug-Like Properties against Two Intracellular Pathogens.

Passalacqua KD, Charbonneau ME, Donato NJ, Showalter HD, Sun D, Wen B, He M, Sun H, O'Riordan MX, Wobus CE. Passalacqua KD, et al. Among authors: he m. Antimicrob Agents Chemother. 2016 Jun 20;60(7):4183-96. doi: 10.1128/AAC.03021-15. Print 2016 Jul. Antimicrob Agents Chemother. 2016. PMID: 27139470 Free PMC article.

4

Elimination of epithelial-like and mesenchymal-like breast cancer stem cells to inhibit metastasis following nanoparticle-mediated photothermal therapy.

Paholak HJ, Stevers NO, Chen H, Burnett JP, He M, Korkaya H, McDermott SP, Deol Y, Clouthier SG, Luther T, Li Q, Wicha MS, Sun D. Paholak HJ, et al. Among authors: he m. Biomaterials. 2016 Oct;104:145-57. doi: 10.1016/j.biomaterials.2016.06.045. Epub 2016 Jun 23. Biomaterials. 2016. PMID: 27450902 Free PMC article.

5

Distinct biodistribution of doxorubicin and the altered dispositions mediated by different liposomal formulations.

Luo R, Li Y, He M, Zhang H, Yuan H, Johnson M, Palmisano M, Zhou S, Sun D. Luo R, et al. Among authors: he m. Int J Pharm. 2017 Mar 15;519(1-2):1-10. doi: 10.1016/j.ijpharm.2017.01.002. Epub 2017 Jan 4. Int J Pharm. 2017. PMID: 28063903

6

Design, Synthesis, and Biological Evaluation of 4-Quinoline Carboxylic Acids as Inhibitors of Dihydroorotate Dehydrogenase.

Madak JT, Cuthbertson CR, Miyata Y, Tamura S, Petrunak EM, Stuckey JA, Han Y, He M, Sun D, Showalter HD, Neamati N. Madak JT, et al. Among authors: he m. J Med Chem. 2018 Jun 28;61(12):5162-5186. doi: 10.1021/acs.jmedchem.7b01862. Epub 2018 May 14. J Med Chem. 2018. PMID: 29727569 Free PMC article.

7

Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.

Borkin D, Klossowski S, Pollock J, Miao H, Linhares BM, Kempinska K, Jin Z, Purohit T, Wen B, He M, Sun D, Cierpicki T, Grembecka J. Borkin D, et al. Among authors: he m. J Med Chem. 2018 Jun 14;61(11):4832-4850. doi: 10.1021/acs.jmedchem.8b00071. Epub 2018 May 23. J Med Chem. 2018. PMID: 29738674 Free PMC article.

8

Different Nanoformulations Alter the Tissue Distribution of Paclitaxel, Which Aligns with Reported Distinct Efficacy and Safety Profiles.

Li F, Zhang H, He M, Liao J, Chen N, Li Y, Zhou S, Palmisano M, Yu A, Pai MP, Yuan H, Sun D. Li F, et al. Among authors: he m. Mol Pharm. 2018 Oct 1;15(10):4505-4516. doi: 10.1021/acs.molpharmaceut.8b00527. Epub 2018 Sep 21. Mol Pharm. 2018. PMID: 30180593 Free PMC article.

9

Species difference in paclitaxel disposition correlated with poor pharmacological efficacy translation from mice to humans.

Li YF, Zhang C, Zhou S, He M, Zhang H, Chen N, Li F, Luan X, Pai M, Yuan H, Sun D, Li Y. Li YF, et al. Among authors: he m. Clin Pharmacol. 2018 Nov 8;10:165-174. doi: 10.2147/CPAA.S185449. eCollection 2018. Clin Pharmacol. 2018. PMID: 30519122 Free PMC article.

10

Neonatal Fc Receptor (FcRn) Enhances Tissue Distribution and Prevents Excretion of nab-Paclitaxel.

Li F, Yuan H, Zhang H, He M, Liao J, Chen N, Li Y, Zhou S, Palmisano M, Yu A, Pai M, Sun D. Li F, et al. Among authors: he m. Mol Pharm. 2019 Jun 3;16(6):2385-2393. doi: 10.1021/acs.molpharmaceut.8b01314. Epub 2019 May 1. Mol Pharm. 2019. PMID: 31002261 Free PMC article.

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