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The safety and toxicity profile of SPL84, an inhaled antisense oligonucleotide for treatment of cystic fibrosis patients with the 3849 +10kb C->T mutation, supports a Phase 1/2 clinical study.
Friedman L, Avitzur OB, Galai EO, Ferrari N, Choen A, Dahan S, Mordechai T, Hart G. Friedman L, et al. Among authors: dahan s. Expert Opin Drug Metab Toxicol. 2023 Jul-Dec;19(10):709-720. doi: 10.1080/17425255.2023.2266361. Epub 2023 Oct 27. Expert Opin Drug Metab Toxicol. 2023. PMID: 37799089
Isoforms of the TAL1 transcription factor have different roles in hematopoiesis and cell growth.
Sharma A, Mistriel-Zerbib S, Najar RA, Engal E, Bentata M, Taqatqa N, Dahan S, Cohen K, Jaffe-Herman S, Geminder O, Baker M, Nevo Y, Plaschkes I, Kay G, Drier Y, Berger M, Salton M. Sharma A, et al. Among authors: dahan s. PLoS Biol. 2023 Jun 28;21(6):e3002175. doi: 10.1371/journal.pbio.3002175. eCollection 2023 Jun. PLoS Biol. 2023. PMID: 37379322 Free PMC article.
180 results