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Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen.
Poole A, Karuppiah V, Hartt A, Haidar JN, Moureau S, Dobrzycki T, Hayes C, Rowley C, Dias J, Harper S, Barnbrook K, Hock M, Coles C, Yang W, Aleksic M, Lin AB, Robinson R, Dukes JD, Liddy N, Van der Kamp M, Plowman GD, Vuidepot A, Cole DK, Whale AD, Chillakuri C. Poole A, et al. Among authors: barnbrook k. Nat Commun. 2022 Sep 10;13(1):5333. doi: 10.1038/s41467-022-32811-1. Nat Commun. 2022. PMID: 36088370 Free PMC article.
Broadening alloselectivity of T cell receptors by structure guided engineering.
Karuppiah V, Sangani D, Whaley L, Pengelly R, Uluocak P, Carreira RJ, Hock M, Cristina PD, Bartasun P, Dobrinic P, Smith N, Barnbrook K, Robinson RA, Harper S. Karuppiah V, et al. Among authors: barnbrook k. Sci Rep. 2024 Nov 6;14(1):26851. doi: 10.1038/s41598-024-75140-7. Sci Rep. 2024. PMID: 39500929 Free PMC article.