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Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics.
Morad SA, Tan SF, Feith DJ, Kester M, Claxton DF, Loughran TP Jr, Barth BM, Fox TE, Cabot MC. Morad SA, et al. Among authors: cabot mc. Biochim Biophys Acta. 2015 Jul;1851(7):919-28. doi: 10.1016/j.bbalip.2015.03.001. Epub 2015 Mar 10. Biochim Biophys Acta. 2015. PMID: 25769964 Free PMC article.
Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia.
Morad SA, Ryan TE, Neufer PD, Zeczycki TN, Davis TS, MacDougall MR, Fox TE, Tan SF, Feith DJ, Loughran TP Jr, Kester M, Claxton DF, Barth BM, Deering TG, Cabot MC. Morad SA, et al. Among authors: cabot mc. J Lipid Res. 2016 Jul;57(7):1231-42. doi: 10.1194/jlr.M067389. Epub 2016 May 2. J Lipid Res. 2016. PMID: 27140664 Free PMC article.
Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia.
Pearson JM, Tan SF, Sharma A, Annageldiyev C, Fox TE, Abad JL, Fabrias G, Desai D, Amin S, Wang HG, Cabot MC, Claxton DF, Kester M, Feith DJ, Loughran TP. Pearson JM, et al. Among authors: cabot mc. Mol Cancer Res. 2020 Mar;18(3):352-363. doi: 10.1158/1541-7786.MCR-19-0619. Epub 2019 Nov 19. Mol Cancer Res. 2020. PMID: 31744877 Free PMC article.
Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia.
Fisher-Wellman KH, Hagen JT, Kassai M, Kao LP, Nelson MAM, McLaughlin KL, Coalson HS, Fox TE, Tan SF, Feith DJ, Kester M, Loughran TP Jr, Claxton DF, Cabot MC. Fisher-Wellman KH, et al. Among authors: cabot mc. FASEB J. 2022 Jan;36(1):e22094. doi: 10.1096/fj.202101194RRR. FASEB J. 2022. PMID: 34888943 Free PMC article.
130 results