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Page 1
Robust deep learning-based protein sequence design using ProteinMPNN.
Dauparas J, Anishchenko I, Bennett N, Bai H, Ragotte RJ, Milles LF, Wicky BIM, Courbet A, de Haas RJ, Bethel N, Leung PJY, Huddy TF, Pellock S, Tischer D, Chan F, Koepnick B, Nguyen H, Kang A, Sankaran B, Bera AK, King NP, Baker D. Dauparas J, et al. Among authors: bethel n. Science. 2022 Oct 7;378(6615):49-56. doi: 10.1126/science.add2187. Epub 2022 Sep 15. Science. 2022. PMID: 36108050 Free PMC article.
Computational design of mechanically coupled axle-rotor protein assemblies.
Courbet A, Hansen J, Hsia Y, Bethel N, Park YJ, Xu C, Moyer A, Boyken SE, Ueda G, Nattermann U, Nagarajan D, Silva DA, Sheffler W, Quispe J, Nord A, King N, Bradley P, Veesler D, Kollman J, Baker D. Courbet A, et al. Among authors: bethel n. Science. 2022 Apr 22;376(6591):383-390. doi: 10.1126/science.abm1183. Epub 2022 Apr 21. Science. 2022. PMID: 35446645 Free PMC article.
Precisely patterned nanofibres made from extendable protein multiplexes.
Bethel NP, Borst AJ, Parmeggiani F, Bick MJ, Brunette TJ, Nguyen H, Kang A, Bera AK, Carter L, Miranda MC, Kibler RD, Lamb M, Li X, Sankaran B, Baker D. Bethel NP, et al. Nat Chem. 2023 Dec;15(12):1664-1671. doi: 10.1038/s41557-023-01314-x. Epub 2023 Sep 4. Nat Chem. 2023. PMID: 37667012 Free PMC article.
Blueprinting extendable nanomaterials with standardized protein blocks.
Huddy TF, Hsia Y, Kibler RD, Xu J, Bethel N, Nagarajan D, Redler R, Leung PJY, Weidle C, Courbet A, Yang EC, Bera AK, Coudray N, Calise SJ, Davila-Hernandez FA, Han HL, Carr KD, Li Z, McHugh R, Reggiano G, Kang A, Sankaran B, Dickinson MS, Coventry B, Brunette TJ, Liu Y, Dauparas J, Borst AJ, Ekiert D, Kollman JM, Bhabha G, Baker D. Huddy TF, et al. Among authors: bethel n. Nature. 2024 Mar;627(8005):898-904. doi: 10.1038/s41586-024-07188-4. Epub 2024 Mar 13. Nature. 2024. PMID: 38480887 Free PMC article.
De novo design of pH-responsive self-assembling helical protein filaments.
Shen H, Lynch EM, Akkineni S, Watson JL, Decarreau J, Bethel NP, Benna I, Sheffler W, Farrell D, DiMaio F, Derivery E, De Yoreo JJ, Kollman J, Baker D. Shen H, et al. Among authors: bethel np. Nat Nanotechnol. 2024 Jul;19(7):1016-1021. doi: 10.1038/s41565-024-01641-1. Epub 2024 Apr 3. Nat Nanotechnol. 2024. PMID: 38570702 Free PMC article.
Local structural flexibility drives oligomorphism in computationally designed protein assemblies.
Khmelinskaia A, Bethel NP, Fatehi F, Antanasijevic A, Borst AJ, Lai SH, Wang JYJ, Mallik BB, Miranda MC, Watkins AM, Ogohara C, Caldwell S, Wu M, Heck AJR, Veesler D, Ward AB, Baker D, Twarock R, King NP. Khmelinskaia A, et al. Among authors: bethel np. bioRxiv [Preprint]. 2023 Oct 19:2023.10.18.562842. doi: 10.1101/2023.10.18.562842. bioRxiv. 2023. PMID: 37905007 Free PMC article. Preprint.
27 results