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Page 1
Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy.
Zhang J, Chen J, Richardson JP, Francis-Newton NJ, Lai PF, Jenkins K, Major MR, Key RE, Stewart ME, Firth-Clark S, Lloyd SM, Newton GK, Perrior TR, Garrod DR, Robinson C. Zhang J, et al. Among authors: perrior tr. ACS Pharmacol Transl Sci. 2022 Aug 12;5(9):735-751. doi: 10.1021/acsptsci.2c00022. eCollection 2022 Sep 9. ACS Pharmacol Transl Sci. 2022. PMID: 36110379 Free PMC article.
The discovery of potent, selective, and reversible inhibitors of the house dust mite peptidase allergen Der p 1: an innovative approach to the treatment of allergic asthma.
Newton GK, Perrior TR, Jenkins K, Major MR, Key RE, Stewart MR, Firth-Clark S, Lloyd SM, Zhang J, Francis-Newton NJ, Richardson JP, Chen J, Lai P, Garrod DR, Robinson C. Newton GK, et al. Among authors: perrior tr. J Med Chem. 2014 Nov 26;57(22):9447-62. doi: 10.1021/jm501102h. Epub 2014 Nov 17. J Med Chem. 2014. PMID: 25365789 Free PMC article.
Nonhuman targets in allergic lung conditions.
Robinson C, Zhang J, Newton GK, Perrior TR. Robinson C, et al. Among authors: perrior tr. Future Med Chem. 2013 Feb;5(2):147-61. doi: 10.4155/fmc.12.204. Future Med Chem. 2013. PMID: 23360140 Review.
Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?
Te Lintel Hekkert M, Newton G, Chapman K, Aqil R, Downham R, Yan R, Merkus D, Whitlock G, Lane CAL, Cawkill D, Perrior T, Duncker DJ, Schneider MD. Te Lintel Hekkert M, et al. Basic Res Cardiol. 2021 May 20;116(1):34. doi: 10.1007/s00395-021-00875-7. Basic Res Cardiol. 2021. PMID: 34018053 Free PMC article.
MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.
Fiedler LR, Chapman K, Xie M, Maifoshie E, Jenkins M, Golforoush PA, Bellahcene M, Noseda M, Faust D, Jarvis A, Newton G, Paiva MA, Harada M, Stuckey DJ, Song W, Habib J, Narasimhan P, Aqil R, Sanmugalingam D, Yan R, Pavanello L, Sano M, Wang SC, Sampson RD, Kanayaganam S, Taffet GE, Michael LH, Entman ML, Tan TH, Harding SE, Low CMR, Tralau-Stewart C, Perrior T, Schneider MD. Fiedler LR, et al. Cell Stem Cell. 2019 Apr 4;24(4):579-591.e12. doi: 10.1016/j.stem.2019.01.013. Epub 2019 Mar 7. Cell Stem Cell. 2019. PMID: 30853557 Free PMC article.
18 results