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On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships.
Selassie CD, Fang ZX, Li RL, Hansch C, Debnath G, Klein TE, Langridge R, Kaufman BT. Selassie CD, et al. Among authors: langridge r. J Med Chem. 1989 Aug;32(8):1895-905. doi: 10.1021/jm00128a035. J Med Chem. 1989. PMID: 2502631
Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s.
Hansch C, Hathaway BA, Guo ZR, Selassie CD, Dietrich SW, Blaney JM, Langridge R, Volz KW, Kaufman BT. Hansch C, et al. Among authors: langridge r. J Med Chem. 1984 Feb;27(2):129-43. doi: 10.1021/jm00368a006. J Med Chem. 1984. PMID: 6420569
90 results