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209 results

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Page 1
Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders.
El Andari J, Renaud-Gabardos E, Tulalamba W, Weinmann J, Mangin L, Pham QH, Hille S, Bennett A, Attebi E, Bourges E, Leborgne C, Guerchet N, Fakhiri J, Krämer C, Wiedtke E, McKenna R, Guianvarc'h L, Toueille M, Ronzitti G, Hebben M, Mingozzi F, VandenDriessche T, Agbandje-McKenna M, Müller OJ, Chuah MK, Buj-Bello A, Grimm D. El Andari J, et al. Among authors: muller oj. Sci Adv. 2022 Sep 23;8(38):eabn4704. doi: 10.1126/sciadv.abn4704. Epub 2022 Sep 21. Sci Adv. 2022. PMID: 36129972 Free PMC article.
Pulmonary Targeting of Adeno-associated Viral Vectors by Next-generation Sequencing-guided Screening of Random Capsid Displayed Peptide Libraries.
Körbelin J, Sieber T, Michelfelder S, Lunding L, Spies E, Hunger A, Alawi M, Rapti K, Indenbirken D, Müller OJ, Pasqualini R, Arap W, Kleinschmidt JA, Trepel M. Körbelin J, et al. Among authors: muller oj. Mol Ther. 2016 Jun;24(6):1050-1061. doi: 10.1038/mt.2016.62. Epub 2016 Mar 28. Mol Ther. 2016. PMID: 27018516 Free PMC article.
Comprehensive plasma and tissue profiling reveals systemic metabolic alterations in cardiac hypertrophy and failure.
Müller OJ, Heckmann MB, Ding L, Rapti K, Rangrez AY, Gerken T, Christiansen N, Rennefahrt UEE, Witt H, González Maldonado S, Ternes P, Schwab DM, Ruf T, Hille S, Remes A, Jungmann A, Weis TM, Kreußer JS, Gröne HJ, Backs J, Schatz P, Katus HA, Frey N. Müller OJ, et al. Cardiovasc Res. 2019 Jul 1;115(8):1296-1305. doi: 10.1093/cvr/cvy274. Cardiovasc Res. 2019. PMID: 30418544
Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants.
Weinmann J, Weis S, Sippel J, Tulalamba W, Remes A, El Andari J, Herrmann AK, Pham QH, Borowski C, Hille S, Schönberger T, Frey N, Lenter M, VandenDriessche T, Müller OJ, Chuah MK, Lamla T, Grimm D. Weinmann J, et al. Among authors: muller oj. Nat Commun. 2020 Oct 28;11(1):5432. doi: 10.1038/s41467-020-19230-w. Nat Commun. 2020. PMID: 33116134 Free PMC article.
Liver alanine catabolism promotes skeletal muscle atrophy and hyperglycaemia in type 2 diabetes.
Okun JG, Rusu PM, Chan AY, Wu Y, Yap YW, Sharkie T, Schumacher J, Schmidt KV, Roberts-Thomson KM, Russell RD, Zota A, Hille S, Jungmann A, Maggi L, Lee Y, Blüher M, Herzig S, Keske MA, Heikenwalder M, Müller OJ, Rose AJ. Okun JG, et al. Among authors: muller oj. Nat Metab. 2021 Mar;3(3):394-409. doi: 10.1038/s42255-021-00369-9. Epub 2021 Mar 18. Nat Metab. 2021. PMID: 33758419
Alginate hydrogel polymers enable efficient delivery of a vascular-targeted AAV vector into aortic tissue.
Remes A, Basha DI, Puehler T, Borowski C, Hille S, Kummer L, Wagner AH, Hecker M, Soethoff J, Lutter G, Frank D, Arif R, Frey N, Zaradzki M, Müller OJ. Remes A, et al. Among authors: muller oj. Mol Ther Methods Clin Dev. 2021 Feb 24;21:83-93. doi: 10.1016/j.omtm.2021.02.017. eCollection 2021 Jun 11. Mol Ther Methods Clin Dev. 2021. PMID: 33768132 Free PMC article.
209 results