Brown MJB - Search Results

1

A designed photoenzyme for enantioselective [2+2] cycloadditions.

Trimble JS, Crawshaw R, Hardy FJ, Levy CW, Brown MJB, Fuerst DE, Heyes DJ, Obexer R, Green AP. Trimble JS, et al. Among authors: brown mjb. Nature. 2022 Nov;611(7937):709-714. doi: 10.1038/s41586-022-05335-3. Epub 2022 Sep 21. Nature. 2022. PMID: 36130727

2

Assembly of nuclear dimers of PI3K regulatory subunits is regulated by the Cdc42-activated tyrosine kinase ACK.

Clayton NS, Fox M, Vicenté-Garcia JJ, Schroeder CM, Littlewood TD, Wilde JI, Krishnan K, Brown MJB, Crafter C, Mott HR, Owen D. Clayton NS, et al. Among authors: brown mjb. J Biol Chem. 2022 Jun;298(6):101916. doi: 10.1016/j.jbc.2022.101916. Epub 2022 Apr 13. J Biol Chem. 2022. PMID: 35429500 Free PMC article.

3

Synthesis and Conformational Analysis of Fluorinated Uridine Analogues Provide Insight into a Neighbouring-Group Participation Mechanism.

Michailidou F, Lebl T, Slawin AMZ, Sharma SV, Brown MJB, Goss RJM. Michailidou F, et al. Among authors: brown mjb. Molecules. 2020 Nov 25;25(23):5513. doi: 10.3390/molecules25235513. Molecules. 2020. PMID: 33255573 Free PMC article.

4

Corrigendum: Pac13 is a Small Dehydratase that Mediates the Formation of the 3'-Deoxy Nucleoside of Pacidamycins.

Michailidou F, Chung CW, Brown MJB, Naismith JH, Leavens WJ, Lynn SM, Sharma SV, Goss RJM. Michailidou F, et al. Among authors: brown mjb. Angew Chem Int Ed Engl. 2020 Jul 27;59(31):12573. doi: 10.1002/anie.202000990. Angew Chem Int Ed Engl. 2020. PMID: 32691957 Free PMC article. No abstract available.

5

Pac13 is a Small, Monomeric Dehydratase that Mediates the Formation of the 3'-Deoxy Nucleoside of Pacidamycins.

Michailidou F, Chung CW, Brown MJB, Bent AF, Naismith JH, Leavens WJ, Lynn SM, Sharma SV, Goss RJM. Michailidou F, et al. Among authors: brown mjb. Angew Chem Int Ed Engl. 2017 Oct 2;56(41):12492-12497. doi: 10.1002/anie.201705639. Epub 2017 Aug 30. Angew Chem Int Ed Engl. 2017. PMID: 28786545 Free PMC article.

6

1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3.

Christopher JA, Atkinson FL, Bax BD, Brown MJ, Champigny AC, Chuang TT, Jones EJ, Mosley JE, Musgrave JR. Christopher JA, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2230-4. doi: 10.1016/j.bmcl.2009.02.098. Epub 2009 Feb 28. Bioorg Med Chem Lett. 2009. PMID: 19303774

7

The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.

Takle AK, Brown MJ, Davies S, Dean DK, Francis G, Gaiba A, Hird AW, King FD, Lovell PJ, Naylor A, Reith AD, Steadman JG, Wilson DM. Takle AK, et al. Bioorg Med Chem Lett. 2006 Jan 15;16(2):378-81. doi: 10.1016/j.bmcl.2005.09.072. Epub 2005 Nov 2. Bioorg Med Chem Lett. 2006. PMID: 16260133

8

The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.

Blackie JA, Bloomer JC, Brown MJ, Cheng HY, Hammond B, Hickey DM, Ife RJ, Leach CA, Lewis VA, Macphee CH, Milliner KJ, Moores KE, Pinto IL, Smith SA, Stansfield IG, Stanway SJ, Taylor MA, Theobald CJ. Blackie JA, et al. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1067-70. doi: 10.1016/s0960-894x(03)00058-1. Bioorg Med Chem Lett. 2003. PMID: 12643913

9

The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man.

Blackie JA, Bloomer JC, Brown MJ, Cheng HY, Elliott RL, Hammond B, Hickey DM, Ife RJ, Leach CA, Lewis VA, Macphee CH, Milliner KJ, Moores KE, Pinto IL, Smith SA, Stansfield IG, Stanway SJ, Taylor MA, Theobald CJ, Whittaker CM. Blackie JA, et al. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2603-6. doi: 10.1016/s0960-894x(02)00473-0. Bioorg Med Chem Lett. 2002. PMID: 12182870

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