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CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target.
Le Q, Hadland B, Smith JL, Leonti A, Huang BJ, Ries R, Hylkema TA, Castro S, Tang TT, McKay CN, Perkins L, Pardo L, Sarthy J, Beckman AK, Williams R, Idemmili R, Furlan S, Ishida T, Call L, Srivastava S, Loeb AM, Milano F, Imren S, Morris SM, Pakiam F, Olson JM, Loken MR, Brodersen L, Riddell SR, Tarlock K, Bernstein ID, Loeb KR, Meshinchi S. Le Q, et al. J Clin Invest. 2022 Nov 15;132(22):e157101. doi: 10.1172/JCI157101. J Clin Invest. 2022. PMID: 36136600 Free PMC article.
Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options: A COG and TARGET Pediatric AML Study.
Smith JL, Ries RE, Hylkema T, Alonzo TA, Gerbing RB, Santaguida MT, Eidenschink Brodersen L, Pardo L, Cummings CL, Loeb KR, Le Q, Imren S, Leonti AR, Gamis AS, Aplenc R, Kolb EA, Farrar JE, Triche TJ Jr, Nguyen C, Meerzaman D, Loken MR, Oehler VG, Bolouri H, Meshinchi S. Smith JL, et al. Among authors: le q. Clin Cancer Res. 2020 Feb 1;26(3):726-737. doi: 10.1158/1078-0432.CCR-19-1800. Epub 2019 Nov 12. Clin Cancer Res. 2020. PMID: 31719049 Free PMC article.
Mesothelin is a novel cell surface disease marker and potential therapeutic target in acute myeloid leukemia.
Kaeding AJ, Barwe SP, Gopalakrishnapillai A, Ries RE, Alonzo TA, Gerbing RB, Correnti C, Loken MR, Broderson LE, Pardo L, Le QH, Tang T, Leonti AR, Smith JL, Chou CK, Xu M, Triche T, Kornblau SM, Kolb EA, Tarlock K, Meshinchi S. Kaeding AJ, et al. Blood Adv. 2021 May 11;5(9):2350-2361. doi: 10.1182/bloodadvances.2021004424. Blood Adv. 2021. PMID: 33938941 Free PMC article.
Therapeutic Targeting of Mesothelin with Chimeric Antigen Receptor T Cells in Acute Myeloid Leukemia.
Le Q, Castro S, Tang T, Loeb AM, Hylkema T, McKay CN, Perkins L, Srivastava S, Call L, Smith J, Leonti A, Ries R, Pardo L, Loken MR, Correnti C, Fiorenza S, Turtle CJ, Riddell S, Tarlock K, Meshinchi S. Le Q, et al. Clin Cancer Res. 2021 Oct 15;27(20):5718-5730. doi: 10.1158/1078-0432.CCR-21-1546. Epub 2021 Aug 11. Clin Cancer Res. 2021. PMID: 34380639 Free PMC article.
Therapeutic targeting of PRAME with mTCRCAR T cells in acute myeloid leukemia.
Kirkey DC, Loeb AM, Castro S, McKay CN, Perkins L, Pardo L, Leonti AR, Tang TT, Loken MR, Brodersen LE, Loeb KR, Scheinberg DA, Le Q, Meshinchi S. Kirkey DC, et al. Among authors: le q. Blood Adv. 2023 Apr 11;7(7):1178-1189. doi: 10.1182/bloodadvances.2022008304. Blood Adv. 2023. PMID: 35984639 Free PMC article.
Preclinical studies targeting CD74 with STRO-001 antibody-drug conjugate in acute leukemia.
Le Q, Tang T, Leonti A, Castro S, McKay CN, Perkins L, Pardo L, Kirkey D, Hylkema T, Call L, Manselle M, Abrahams C, Bedard K, Molina A, Brodersen LE, Loken MR, Tarlock K, Meshinchi S, Loeb KR. Le Q, et al. Blood Adv. 2023 May 9;7(9):1666-1670. doi: 10.1182/bloodadvances.2022008303. Blood Adv. 2023. PMID: 36595452 Free PMC article. No abstract available.
Chromatin Profiling of CBFA2T3-GLIS2 AMLs Identifies Key Transcription Factor Dependencies and BRG1 Inhibition as a Novel Therapeutic Strategy.
Kaonis S, Smith JL, Katiyar N, Merrill M, Hyelkma T, Namciu S, Le Q, Babaeva E, Ishida T, Morris SM, Girard E, Furuyama S, Ries R, Bernstein I, Meshinchi S, Henikoff S, Meers M, Hadland B, Sarthy JF. Kaonis S, et al. Among authors: le q. bioRxiv [Preprint]. 2023 Sep 1:2023.08.30.555598. doi: 10.1101/2023.08.30.555598. bioRxiv. 2023. PMID: 37693371 Free PMC article. Preprint.
CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target.
Le Q, Hadland B, Smith JL, Leonti A, Huang BJ, Ries R, Hylkema TA, Castro S, Tang TT, McKay CN, Perkins L, Pardo L, Sarthy J, Beckman AK, Williams R, Idemmili R, Furlan S, Ishida T, Call L, Srivastava S, Loeb AM, Milano F, Imren S, Morris SM, Pakiam F, Olson JM, Loken MR, Brodersen L, Riddell SR, Tarlock K, Bernstein ID, Loeb KR, Meshinchi S. Le Q, et al. J Clin Invest. 2024 Aug 15;134(16):e184305. doi: 10.1172/JCI184305. J Clin Invest. 2024. PMID: 39145456 Free PMC article. No abstract available.
1,388 results