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6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist.
Cuthbertson P, Elhage A, Al-Rifai D, Sophocleous RA, Turner RJ, Aboelela A, Majed H, Bujaroski RS, Jalilian I, Kelso MJ, Watson D, Buckley BJ, Sluyter R. Cuthbertson P, et al. Among authors: kelso mj. Biomolecules. 2022 Sep 16;12(9):1309. doi: 10.3390/biom12091309. Biomolecules. 2022. PMID: 36139148 Free PMC article.
Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile.
Rajamuthiah R, Jayamani E, Majed H, Conery AL, Kim W, Kwon B, Fuchs BB, Kelso MJ, Ausubel FM, Mylonakis E. Rajamuthiah R, et al. Among authors: kelso mj. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5203-7. doi: 10.1016/j.bmcl.2015.09.066. Epub 2015 Sep 30. Bioorg Med Chem Lett. 2015. PMID: 26459212 Free PMC article.
6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
Buckley BJ, Aboelela A, Minaei E, Jiang LX, Xu Z, Ali U, Fildes K, Cheung CY, Cook SM, Johnson DC, Bachovchin DA, Cook GM, Apte M, Huang M, Ranson M, Kelso MJ. Buckley BJ, et al. Among authors: kelso mj. J Med Chem. 2018 Sep 27;61(18):8299-8320. doi: 10.1021/acs.jmedchem.8b00838. Epub 2018 Sep 7. J Med Chem. 2018. PMID: 30130401 Free PMC article.
6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease.
Buckley BJ, Majed H, Aboelela A, Minaei E, Jiang L, Fildes K, Cheung CY, Johnson D, Bachovchin D, Cook GM, Huang M, Ranson M, Kelso MJ. Buckley BJ, et al. Among authors: kelso mj. Bioorg Med Chem Lett. 2019 Dec 15;29(24):126753. doi: 10.1016/j.bmcl.2019.126753. Epub 2019 Oct 28. Bioorg Med Chem Lett. 2019. PMID: 31679971 Free PMC article.
Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride.
Buckley BJ, Aboelela A, Majed H, Bujaroski RS, White KL, Powell AK, Wang W, Katneni K, Saunders J, Shackleford DM, Charman SA, Cook GM, Kelso MJ, Ranson M. Buckley BJ, et al. Among authors: kelso mj. Bioorg Med Chem. 2021 May 1;37:116116. doi: 10.1016/j.bmc.2021.116116. Epub 2021 Mar 23. Bioorg Med Chem. 2021. PMID: 33799173
73 results