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Computational identification of a systemic antibiotic for gram-negative bacteria.
Miller RD, Iinishi A, Modaresi SM, Yoo BK, Curtis TD, Lariviere PJ, Liang L, Son S, Nicolau S, Bargabos R, Morrissette M, Gates MF, Pitt N, Jakob RP, Rath P, Maier T, Malyutin AG, Kaiser JT, Niles S, Karavas B, Ghiglieri M, Bowman SEJ, Rees DC, Hiller S, Lewis K. Miller RD, et al. Among authors: lewis k. Nat Microbiol. 2022 Oct;7(10):1661-1672. doi: 10.1038/s41564-022-01227-4. Epub 2022 Sep 26. Nat Microbiol. 2022. PMID: 36163500 Free PMC article.
Persister cells.
Lewis K. Lewis K. Annu Rev Microbiol. 2010;64:357-72. doi: 10.1146/annurev.micro.112408.134306. Annu Rev Microbiol. 2010. PMID: 20528688 Review.
Tackling antibiotic resistance.
Bush K, Courvalin P, Dantas G, Davies J, Eisenstein B, Huovinen P, Jacoby GA, Kishony R, Kreiswirth BN, Kutter E, Lerner SA, Levy S, Lewis K, Lomovskaya O, Miller JH, Mobashery S, Piddock LJ, Projan S, Thomas CM, Tomasz A, Tulkens PM, Walsh TR, Watson JD, Witkowski J, Witte W, Wright G, Yeh P, Zgurskaya HI. Bush K, et al. Among authors: lewis k. Nat Rev Microbiol. 2011 Nov 2;9(12):894-6. doi: 10.1038/nrmicro2693. Nat Rev Microbiol. 2011. PMID: 22048738 Free PMC article. Review.
Platforms for antibiotic discovery.
Lewis K. Lewis K. Nat Rev Drug Discov. 2013 May;12(5):371-87. doi: 10.1038/nrd3975. Nat Rev Drug Discov. 2013. PMID: 23629505 Review.
Activated ClpP kills persisters and eradicates a chronic biofilm infection.
Conlon BP, Nakayasu ES, Fleck LE, LaFleur MD, Isabella VM, Coleman K, Leonard SN, Smith RD, Adkins JN, Lewis K. Conlon BP, et al. Among authors: lewis k. Nature. 2013 Nov 21;503(7476):365-70. doi: 10.1038/nature12790. Epub 2013 Nov 13. Nature. 2013. PMID: 24226776 Free PMC article.
A new antibiotic kills pathogens without detectable resistance.
Ling LL, Schneider T, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K. Ling LL, et al. Among authors: lewis k. Nature. 2015 Jan 22;517(7535):455-9. doi: 10.1038/nature14098. Epub 2015 Jan 7. Nature. 2015. PMID: 25561178 Free PMC article.
2,577 results