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Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional in vitro models.
Monzer A, Wakimian K, Ballout F, Al Bitar S, Yehya A, Kanso M, Saheb N, Tawil A, Doughan S, Hussein M, Mukherji D, Faraj W, Gali-Muhtasib H, Abou-Kheir W. Monzer A, et al. Among authors: wakimian k. World J Gastroenterol. 2022 Sep 7;28(33):4787-4811. doi: 10.3748/wjg.v28.i33.4787. World J Gastroenterol. 2022. PMID: 36156922 Free PMC article.
ONC206, an imipridone derivative, demonstrates anti-colorectal cancer activity against stem/progenitor cells in 3D cell cultures and in patient-derived organoids.
Monzer A, Ghamlouche F, Wakimian K, Ballout F, Al Bitar S, Yehya A, Kanso M, Saheb N, Tawil A, Doughan S, Hussein M, Mukherji D, Faraj W, Allen JE, Prabhu VV, Abou-Antoun T, Gali-Muhtasib H, Abou-Kheir W. Monzer A, et al. Among authors: wakimian k. Pharmacol Rep. 2024 Nov 18. doi: 10.1007/s43440-024-00676-4. Online ahead of print. Pharmacol Rep. 2024. PMID: 39551911