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BioMedGraphica: An All-in-One Platform for Biomedical Prior Knowledge and Omic Signaling Graph Generation.
Zhang H, Liang S, Xu T, Li W, Huang D, Dong Y, Li G, Miller JP, Goedegebuure SP, Sardiello M, Cooper J, Buchser W, Dickson P, Fields RC, Cruchaga C, Chen Y, Province M, Payne P, Li F. Zhang H, et al. Among authors: cruchaga c. bioRxiv [Preprint]. 2024 Dec 9:2024.12.05.627020. doi: 10.1101/2024.12.05.627020. bioRxiv. 2024. PMID: 39713411 Free PMC article. Preprint.
Neuroinflammation in Alzheimer disease.
Heneka MT, van der Flier WM, Jessen F, Hoozemanns J, Thal DR, Boche D, Brosseron F, Teunissen C, Zetterberg H, Jacobs AH, Edison P, Ramirez A, Cruchaga C, Lambert JC, Laza AR, Sanchez-Mut JV, Fischer A, Castro-Gomez S, Stein TD, Kleineidam L, Wagner M, Neher JJ, Cunningham C, Singhrao SK, Prinz M, Glass CK, Schlachetzki JCM, Butovsky O, Kleemann K, De Jaeger PL, Scheiblich H, Brown GC, Landreth G, Moutinho M, Grutzendler J, Gomez-Nicola D, McManus RM, Andreasson K, Ising C, Karabag D, Baker DJ, Liddelow SA, Verkhratsky A, Tansey M, Monsonego A, Aigner L, Dorothée G, Nave KA, Simons M, Constantin G, Rosenzweig N, Pascual A, Petzold GC, Kipnis J, Venegas C, Colonna M, Walter J, Tenner AJ, O'Banion MK, Steinert JR, Feinstein DL, Sastre M, Bhaskar K, Hong S, Schafer DP, Golde T, Ransohoff RM, Morgan D, Breitner J, Mancuso R, Riechers SP. Heneka MT, et al. Among authors: cruchaga c. Nat Rev Immunol. 2024 Dec 9. doi: 10.1038/s41577-024-01104-7. Online ahead of print. Nat Rev Immunol. 2024. PMID: 39653749 Review.
X-chromosome-wide association study for Alzheimer's disease.
Le Borgne J, Gomez L, Heikkinen S, Amin N, Ahmad S, Choi SH, Bis J, Grenier-Boley B, Rodriguez OG, Kleineidam L, Young J, Tripathi KP, Wang L, Varma A, Campos-Martin R, van der Lee S, Damotte V, de Rojas I, Palmal S; EADB, GR@ACE, DEGESCO, EADI, GERAD, DemGene, FinnGen, ADGC, CHARGE; Lipton R, Reiman E, McKee A, De Jager P, Bush W, Small S, Levey A, Saykin A, Foroud T, Albert M, Hyman B, Petersen R, Younkin S, Sano M, Wisniewski T, Vassar R, Schneider J, Henderson V, Roberson E, DeCarli C, LaFerla F, Brewer J, Swerdlow R, Van Eldik L, Hamilton-Nelson K, Paulson H, Naj A, Lopez O, Chui H, Crane P, Grabowski T, Kukull W, Asthana S, Craft S, Strittmatter S, Cruchaga C, Leverenz J, Goate A, Kamboh MI, George-Hyslop PS, Valladares O, Kuzma A, Cantwell L, Riemenschneider M, Morris J, Slifer S, Dalmasso C, Castillo A, Küçükali F, Peters O, Schneider A, Dichgans M, Rujescu D, Scherbaum N, Deckert J, Riedel-Heller S, Hausner L, Molina-Porcel L, Düzel E, Grimmer T, Wiltfang J, Heilmann-Heimbach S, Moebus S, Tegos T, Scarmeas N, Dols-Icardo O, Moreno F, Pérez-Tur J, Bullido MJ, Pastor P, Sánchez-Valle R, Álvarez V, Boada M, García-González P, Puerta R, Mir P, Real LM, Piñol-Ripoll G, … See abstract for full author list ➔ Le Borgne J, et al. Among authors: cruchaga c. Mol Psychiatry. 2024 Dec 4. doi: 10.1038/s41380-024-02838-5. Online ahead of print. Mol Psychiatry. 2024. PMID: 39633006
Benchmarking of a multi-biomarker low-volume panel for Alzheimer's disease and related dementia research.
Ibanez L, Liu M, Beric A, Timsina J, Kohlfeld P, Bergmann K, Lowery J, Sykora N, Sanchez-Montejo B, Brock W, Budde JP, Bateman RJ, Barthelemy N, Schindler SE, Holtzman DM, Benzinger TLS, Xiong C, Tarawneh R, Moulder K, Morris JC, Sung YJ, Cruchaga C. Ibanez L, et al. Among authors: cruchaga c. Alzheimers Dement. 2024 Nov 22. doi: 10.1002/alz.14413. Online ahead of print. Alzheimers Dement. 2024. PMID: 39575871
Comparative neurofilament light chain trajectories in CSF and plasma in autosomal dominant Alzheimer's disease.
Hofmann A, Häsler LM, Lambert M, Kaeser SA, Gräber-Sultan S, Obermüller U, Kuder-Buletta E, la Fougere C, Laske C, Vöglein J, Levin J, Fox NC, Ryan NS, Zetterberg H, Llibre-Guerra JJ, Perrin RJ, Ibanez L, Schofield PR, Brooks WS, Day GS, Farlow MR, Allegri RF, Chrem Mendez P, Ikeuchi T, Kasuga K, Lee JH, Roh JH, Mori H, Lopera F, Bateman RJ, McDade E, Gordon BA, Chhatwal JP, Jucker M, Schultz SA; Dominantly Inherited Alzheimer Network. Hofmann A, et al. Nat Commun. 2024 Nov 18;15(1):9982. doi: 10.1038/s41467-024-52937-8. Nat Commun. 2024. PMID: 39557867 Free PMC article.
Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits.
Wang C, Yang C, Western D, Ali M, Wang Y, Phuah CL, Budde J, Wang L, Gorijala P, Timsina J, Ruiz A, Pastor P, Fernandez MV; Dominantly Inherited Alzheimer Network (DIAN); Alzheimer’s Disease Neuroimaging Initiative (ADNI); Panyard DJ, Engelman CD, Deming Y, Boada M, Cano A, Garcia-Gonzalez P, Graff-Radford NR, Mori H, Lee JH, Perrin RJ, Ibanez L, Sung YJ, Cruchaga C. Wang C, et al. Among authors: cruchaga c. Nat Genet. 2024 Dec;56(12):2685-2695. doi: 10.1038/s41588-024-01973-7. Epub 2024 Nov 11. Nat Genet. 2024. PMID: 39528826
Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer's disease.
Western D, Timsina J, Wang L, Wang C, Yang C, Phillips B, Wang Y, Liu M, Ali M, Beric A, Gorijala P, Kohlfeld P, Budde J, Levey AI, Morris JC, Perrin RJ, Ruiz A, Marquié M, Boada M, de Rojas I, Rutledge J, Oh H, Wilson EN, Le Guen Y, Reus LM, Tijms B, Visser PJ, van der Lee SJ, Pijnenburg YAL, Teunissen CE, Del Campo Milan M, Alvarez I, Aguilar M; Dominantly Inherited Alzheimer Network (DIAN); Alzheimer’s Disease Neuroimaging Initiative (ADNI); Greicius MD, Pastor P, Pulford DJ, Ibanez L, Wyss-Coray T, Sung YJ, Cruchaga C. Western D, et al. Among authors: cruchaga c. Nat Genet. 2024 Dec;56(12):2672-2684. doi: 10.1038/s41588-024-01972-8. Epub 2024 Nov 11. Nat Genet. 2024. PMID: 39528825
Polygenic proxies of age-related plasma protein levels reveal TIMP2 role in cognitive performance.
Anastasi F, Genius P, Rodriguez-Fernandez B, Yang C, Gorijala P, Timsina J, Hernández-Villamizar F, Lorenzini L, Del Campo M, Sanchez-Benavides G, Minguillon C, Navarro A, Cruchaga C, Suárez-Calvet M, Vilor-Tejedor N. Anastasi F, et al. Among authors: cruchaga c. Res Sq [Preprint]. 2024 Oct 18:rs.3.rs-5267673. doi: 10.21203/rs.3.rs-5267673/v1. Res Sq. 2024. PMID: 39483923 Free PMC article. Preprint.
441 results