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The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement.
Brinkhaus M, Pannecoucke E, van der Kooi EJ, Bentlage AEH, Derksen NIL, Andries J, Balbino B, Sips M, Ulrichts P, Verheesen P, de Haard H, Rispens T, Savvides SN, Vidarsson G. Brinkhaus M, et al. Among authors: savvides sn. Nat Commun. 2022 Oct 14;13(1):6073. doi: 10.1038/s41467-022-33764-1. Nat Commun. 2022. PMID: 36241613 Free PMC article.
Structural basis of IL-23 antagonism by an Alphabody protein scaffold.
Desmet J, Verstraete K, Bloch Y, Lorent E, Wen Y, Devreese B, Vandenbroucke K, Loverix S, Hettmann T, Deroo S, Somers K, Henderikx P, Lasters I, Savvides SN. Desmet J, et al. Among authors: savvides sn. Nat Commun. 2014 Oct 30;5:5237. doi: 10.1038/ncomms6237. Nat Commun. 2014. PMID: 25354530 Free PMC article.
Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Felix J, Kandiah E, De Munck S, Bloch Y, van Zundert GC, Pauwels K, Dansercoer A, Novanska K, Read RJ, Bonvin AM, Vergauwen B, Verstraete K, Gutsche I, Savvides SN. Felix J, et al. Among authors: savvides sn. Nat Commun. 2016 Nov 7;7:13228. doi: 10.1038/ncomms13228. Nat Commun. 2016. PMID: 27819269 Free PMC article.
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma.
Verstraete K, Peelman F, Braun H, Lopez J, Van Rompaey D, Dansercoer A, Vandenberghe I, Pauwels K, Tavernier J, Lambrecht BN, Hammad H, De Winter H, Beyaert R, Lippens G, Savvides SN. Verstraete K, et al. Among authors: savvides sn. Nat Commun. 2017 Apr 3;8:14937. doi: 10.1038/ncomms14937. Nat Commun. 2017. PMID: 28368013 Free PMC article.
Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.
Dondelinger Y, Delanghe T, Priem D, Wynosky-Dolfi MA, Sorobetea D, Rojas-Rivera D, Giansanti P, Roelandt R, Gropengiesser J, Ruckdeschel K, Savvides SN, Heck AJR, Vandenabeele P, Brodsky IE, Bertrand MJM. Dondelinger Y, et al. Among authors: savvides sn. Nat Commun. 2019 Apr 15;10(1):1729. doi: 10.1038/s41467-019-09690-0. Nat Commun. 2019. PMID: 30988283 Free PMC article.
Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms.
Durham BH, Lopez Rodrigo E, Picarsic J, Abramson D, Rotemberg V, De Munck S, Pannecoucke E, Lu SX, Pastore A, Yoshimi A, Mandelker D, Ceyhan-Birsoy O, Ulaner GA, Walsh M, Yabe M, Petrova-Drus K, Arcila ME, Ladanyi M, Solit DB, Berger MF, Hyman DM, Lacouture ME, Erickson C, Saganty R, Ki M, Dunkel IJ, Santa-María López V, Mora J, Haroche J, Emile JF, Decaux O, Geissmann F, Savvides SN, Drilon A, Diamond EL, Abdel-Wahab O. Durham BH, et al. Among authors: savvides sn. Nat Med. 2019 Dec;25(12):1839-1842. doi: 10.1038/s41591-019-0653-6. Epub 2019 Nov 25. Nat Med. 2019. PMID: 31768065 Free PMC article.
Cell-penetrating Alphabody protein scaffolds for intracellular drug targeting.
Pannecoucke E, Van Trimpont M, Desmet J, Pieters T, Reunes L, Demoen L, Vuylsteke M, Loverix S, Vandenbroucke K, Alard P, Henderikx P, Deroo S, Baatz F, Lorent E, Thiolloy S, Somers K, McGrath Y, Van Vlierberghe P, Lasters I, Savvides SN. Pannecoucke E, et al. Among authors: savvides sn. Sci Adv. 2021 Mar 26;7(13):eabe1682. doi: 10.1126/sciadv.abe1682. Print 2021 Mar. Sci Adv. 2021. PMID: 33771865 Free PMC article.
Engineering and crystal structure of a monomeric FLT3 ligand variant.
Pannecoucke E, Raes L, Savvides SN. Pannecoucke E, et al. Among authors: savvides sn. Acta Crystallogr F Struct Biol Commun. 2021 Apr 1;77(Pt 4):121-127. doi: 10.1107/S2053230X21003289. Epub 2021 Apr 6. Acta Crystallogr F Struct Biol Commun. 2021. PMID: 33830077 Free PMC article.
138 results