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AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors.
Dunn S, Eberlein C, Yu J, Gris-Oliver A, Ong SH, Yelland U, Cureton N, Staniszewska A, McEwen R, Fox M, Pilling J, Hopcroft P, Coker EA, Jaaks P, Garnett MJ, Isherwood B, Serra V, Davies BR, Barry ST, Lynch JT, Yusa K. Dunn S, et al. Among authors: isherwood b. Oncogene. 2022 Nov;41(46):5046-5060. doi: 10.1038/s41388-022-02482-9. Epub 2022 Oct 14. Oncogene. 2022. PMID: 36241868 Free PMC article.
The global hearing therapeutic pipeline: 2021.
Isherwood B, Gonçalves AC, Cousins R, Holme R. Isherwood B, et al. Drug Discov Today. 2022 Mar;27(3):912-922. doi: 10.1016/j.drudis.2021.11.009. Epub 2021 Nov 11. Drug Discov Today. 2022. PMID: 34775104 Review.
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