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The natural product argentatin C attenuates postoperative pain via inhibition of voltage-gated sodium and T-type voltage-gated calcium channels.
Duran P, Loya-López S, Ran D, Tang C, Calderon-Rivera A, Gomez K, Stratton HJ, Huang S, Xu YM, Wijeratne EMK, Perez-Miller S, Shan Z, Cai S, Gabrielsen AT, Dorame A, Masterson KA, Alsbiei O, Madura CL, Luo G, Moutal A, Streicher J, Zamponi GW, Gunatilaka AAL, Khanna R. Duran P, et al. Br J Pharmacol. 2023 May;180(9):1267-1285. doi: 10.1111/bph.15974. Epub 2023 Jan 15. Br J Pharmacol. 2023. PMID: 36245395 Free article.
Cdk5 phosphorylates CaV1.3 channels and regulates GABAA-mediated miniature inhibitory post-synaptic currents in striato-nigral terminals.
Loya-López S, Sandoval A, González-Ramírez R, Calderón-Rivera A, Ávalos-Fuentes A, Rodríguez-Sánchez M, Caballero R, Tovar-Soto D, Felix R, Florán B. Loya-López S, et al. Biochem Biophys Res Commun. 2020 Mar 26;524(1):255-261. doi: 10.1016/j.bbrc.2020.01.084. Epub 2020 Jan 23. Biochem Biophys Res Commun. 2020. PMID: 31983427
Betulinic acid analogs inhibit N- and T-type voltage-gated calcium channels to attenuate nerve-injury associated neuropathic and formalin models of pain.
Calderon-Rivera A, Gomez K, Loya-López S, Wijeratne EMK, Stratton H, Tang C, Duran P, Masterson K, Alsbiei O, Gunatilaka AAL, Khanna R. Calderon-Rivera A, et al. Neurobiol Pain. 2023 Jan 14;13:100116. doi: 10.1016/j.ynpai.2023.100116. eCollection 2023 Jan-Jul. Neurobiol Pain. 2023. PMID: 36687466 Free PMC article.
The Ca2+ channel ORAI1 is a regulator of oral cancer growth and nociceptive pain.
Son GY, Tu NH, Santi MD, Loya Lopez S, Souza Bomfim GH, Vinu M, Zhou F, Chaloemtoem A, Alhariri R, Idaghdour Y, Khanna R, Ye Y, Lacruz RS. Son GY, et al. Sci Signal. 2023 Sep 5;16(801):eadf9535. doi: 10.1126/scisignal.adf9535. Epub 2023 Sep 5. Sci Signal. 2023. PMID: 37669398 Free PMC article.
Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain.
Gomez K, Allen HN, Duran P, Loya-Lopez S, Calderon-Rivera A, Moutal A, Tang C, Nelson TS, Perez-Miller S, Khanna R. Gomez K, et al. Among authors: loya lopez s. Pain. 2024 Apr 1;165(4):866-883. doi: 10.1097/j.pain.0000000000003080. Epub 2023 Oct 20. Pain. 2024. PMID: 37862053 Free PMC article.
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