Nagase T - Search Results

1

Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor.

Tamanini E, Miyamura S, Buck IM, Cons BD, Dawson L, East C, Futamura T, Goto S, Griffiths-Jones C, Hashimoto T, Heightman TD, Ishikawa S, Ito H, Kaneko Y, Kawato T, Kondo K, Kurihara N, McCarthy JM, Mori Y, Nagase T, Nakaishi Y, Reeks J, Sato A, Schöpf P, Tai K, Tamai T, Tisi D, Woolford AJ. Tamanini E, et al. Among authors: nagase t. ACS Med Chem Lett. 2022 Sep 6;13(10):1591-1597. doi: 10.1021/acsmedchemlett.2c00272. eCollection 2022 Oct 13. ACS Med Chem Lett. 2022. PMID: 36262388 Free PMC article.

2

Discovery of novel benzoxazinones as potent and orally active long chain fatty acid elongase 6 inhibitors.

Mizutani T, Ishikawa S, Nagase T, Takahashi H, Fujimura T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Mizutani T, et al. Among authors: nagase t. J Med Chem. 2009 Nov 26;52(22):7289-300. doi: 10.1021/jm900915x. J Med Chem. 2009. PMID: 19883081

3

Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

Takahashi T, Nagase T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Takahashi T, et al. Among authors: nagase t. J Med Chem. 2009 May 28;52(10):3142-5. doi: 10.1021/jm900391x. J Med Chem. 2009. PMID: 19388647

4

Synthesis, structure-activity relationships, and biological profiles of a quinazolinone class of histamine H3 receptor inverse agonists.

Nagase T, Mizutani T, Ishikawa S, Sekino E, Sasaki T, Fujimura T, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, Fukami T, Sato N. Nagase T, et al. J Med Chem. 2008 Aug 14;51(15):4780-9. doi: 10.1021/jm8003834. Epub 2008 Jul 4. J Med Chem. 2008. PMID: 18598020

5

Synthesis and evaluation of structurally constrained quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists.

Nagase T, Mizutani T, Sekino E, Ishikawa S, Ito S, Mitobe Y, Miyamoto Y, Yoshimoto R, Tanaka T, Ishihara A, Takenaga N, Tokita S, Sato N. Nagase T, et al. J Med Chem. 2008 Nov 13;51(21):6889-901. doi: 10.1021/jm800569w. Epub 2008 Oct 8. J Med Chem. 2008. PMID: 18841880

6

Synthesis and biological evaluation of a novel 3-sulfonyl-8-azabicyclo[3.2.1]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

Nagase T, Takahashi T, Sasaki T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Nagase T, et al. J Med Chem. 2009 Jul 23;52(14):4111-4. doi: 10.1021/jm900488k. J Med Chem. 2009. PMID: 19522500

7

Development of a selective and potent radioactive ligand for histamine H(3) receptors: A compound potentially useful for receptor occupancy studies.

Mitobe Y, Ito S, Mizutani T, Nagase T, Sato N, Tokita S. Mitobe Y, et al. Among authors: nagase t. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4075-8. doi: 10.1016/j.bmcl.2009.06.025. Epub 2009 Jun 13. Bioorg Med Chem Lett. 2009. PMID: 19553110

8

Synthesis, structure-activity relationships, and biological profiles of a dihydrobenzoxathiin class of histamine H(3) receptor inverse agonists.

Sasaki T, Takahashi T, Nagase T, Mizutani T, Ito S, Mitobe Y, Miyamoto Y, Kanesaka M, Yoshimoto R, Tanaka T, Takenaga N, Tokita S, Sato N. Sasaki T, et al. Among authors: nagase t. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4232-6. doi: 10.1016/j.bmcl.2009.05.101. Epub 2009 May 30. Bioorg Med Chem Lett. 2009. PMID: 19520574

9

Development of novel 2-[4-(aminoalkoxy)phenyl]-4(3H)-quinazolinone derivatives as potent and selective histamine H3 receptor inverse agonists.

Mizutani T, Nagase T, Ito S, Miyamoto Y, Tanaka T, Takenaga N, Tokita S, Sato N. Mizutani T, et al. Among authors: nagase t. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6041-5. doi: 10.1016/j.bmcl.2008.10.034. Epub 2008 Oct 11. Bioorg Med Chem Lett. 2008. PMID: 18952421

10

Synthesis and evaluation of a novel 2-azabicyclo[2.2.2]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.

Sasaki T, Nagase T, Takahashi T, Nagumo A, Shimamura K, Miyamoto Y, Kitazawa H, Kanesaka M, Yoshimoto R, Aragane K, Tokita S, Sato N. Sasaki T, et al. Among authors: nagase t. Bioorg Med Chem. 2009 Aug 1;17(15):5639-47. doi: 10.1016/j.bmc.2009.06.042. Epub 2009 Jun 26. Bioorg Med Chem. 2009. PMID: 19596583

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