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Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.
McBride C, Trzoss L, Povero D, Lazic M, Ambrus-Aikelin G, Santini A, Pranadinata R, Bain G, Stansfield R, Stafford JA, Veal J, Takahashi R, Ly J, Chen S, Liu L, Nespi M, Blake R, Katewa A, Kleinheinz T, Sujatha-Bhaskar S, Ramamoorthi N, Sims J, McKenzie B, Chen M, Ultsch M, Johnson M, Murray J, Ciferri C, Staben ST, Townsend MJ, Stivala CE. McBride C, et al. Among authors: bain g. J Med Chem. 2022 Nov 10;65(21):14721-14739. doi: 10.1021/acs.jmedchem.2c01250. Epub 2022 Oct 24. J Med Chem. 2022. PMID: 36279149
Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis.
Povero D, Lazic M, McBride C, Ambrus-Aikelin G, Stansfield R, Johnson CD, Santini AM, Pranadinata RF, McGeough MD, Stafford JA, Hoffman HM, Feldstein AE, Veal JM, Bain G. Povero D, et al. Among authors: bain g. J Pharmacol Exp Ther. 2023 Aug;386(2):242-258. doi: 10.1124/jpet.123.001639. Epub 2023 Jun 12. J Pharmacol Exp Ther. 2023. PMID: 37308266
JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Ambrus-Aikelin G, Takeda K, Joetham A, Lazic M, Povero D, Santini AM, Pranadinata R, Johnson CD, McGeough MD, Beasley FC, Stansfield R, McBride C, Trzoss L, Hoffman HM, Feldstein AE, Stafford JA, Veal JM, Bain G, Gelfand EW. Ambrus-Aikelin G, et al. Among authors: bain g. Sci Rep. 2023 Aug 19;13(1):13524. doi: 10.1038/s41598-023-39805-z. Sci Rep. 2023. PMID: 37598239 Free PMC article.
Author Correction: JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders.
Ambrus-Aikelin G, Takeda K, Joetham A, Lazic M, Povero D, Santini AM, Pranadinata R, Johnson CD, McGeough MD, Beasley FC, Stansfield R, McBride C, Trzoss L, Hoffman HM, Feldstein AE, Stafford JA, Veal JM, Bain G, Gelfand EW. Ambrus-Aikelin G, et al. Among authors: bain g. Sci Rep. 2023 Nov 16;13(1):20081. doi: 10.1038/s41598-023-47251-0. Sci Rep. 2023. PMID: 37973811 Free PMC article. No abstract available.
Advanced Surgical Training Models for Wrist Surgery.
Maclean SBM, Bain GI. Maclean SBM, et al. Among authors: bain gi. J Hand Surg Asian Pac Vol. 2025 Jan 5. doi: 10.1142/S242483552597001X. Online ahead of print. J Hand Surg Asian Pac Vol. 2025. PMID: 39773155
Detection, classification, and characterization of proximal humerus fractures on plain radiographs.
Spek RWA, Smith WJ, Sverdlov M, Broos S, Zhao Y, Liao Z, Verjans JW, Prijs J, To MS, Åberg H, Chiri W, IJpma FFA, Jadav B, White J, Bain GI, Jutte PC, van den Bekerom MPJ, Jaarsma RL, Doornberg JN; Machine Learning Consortium; Machine Learning Consortium; Ashkani S, Assink N, Colaris JW, der Gaast NV, Jayakumar P, Kim LJ, de Klerk HH, Kuipers J, Mallee WH, Meesters AML, Mennes SRJ, Oldhof MGE, Pijpker PAJ, Yiu Lau C, Wijffels MME, Wolf AD. Spek RWA, et al. Among authors: bain gi. Bone Joint J. 2024 Nov 1;106-B(11):1348-1360. doi: 10.1302/0301-620X.106B11.BJJ-2024-0264.R1. Bone Joint J. 2024. PMID: 39481431
370 results