Georgiadis C - Search Results

1

Phase 1 clinical trial of CRISPR-engineered CAR19 universal T cells for treatment of children with refractory B cell leukemia.

Ottaviano G, Georgiadis C, Gkazi SA, Syed F, Zhan H, Etuk A, Preece R, Chu J, Kubat A, Adams S, Veys P, Vora A, Rao K, Qasim W; TT52 CRISPR-CAR group. Ottaviano G, et al. Among authors: georgiadis c. Sci Transl Med. 2022 Oct 26;14(668):eabq3010. doi: 10.1126/scitranslmed.abq3010. Epub 2022 Oct 26. Sci Transl Med. 2022. PMID: 36288281 Clinical Trial.

2

Lentiviral Engineered Fibroblasts Expressing Codon-Optimized COL7A1 Restore Anchoring Fibrils in RDEB.

Georgiadis C, Syed F, Petrova A, Abdul-Wahab A, Lwin SM, Farzaneh F, Chan L, Ghani S, Fleck RA, Glover L, McMillan JR, Chen M, Thrasher AJ, McGrath JA, Di WL, Qasim W. Georgiadis C, et al. J Invest Dermatol. 2016 Jan;136(1):284-92. doi: 10.1038/JID.2015.364. J Invest Dermatol. 2016. PMID: 26763448 Free PMC article.

3

Emerging applications of gene edited T cells for the treatment of leukemia.

Georgiadis C, Qasim W. Georgiadis C, et al. Expert Rev Hematol. 2017 Sep;10(9):753-755. doi: 10.1080/17474086.2017.1350575. Epub 2017 Jul 25. Expert Rev Hematol. 2017. PMID: 28675317 No abstract available.

4

Long Terminal Repeat CRISPR-CAR-Coupled "Universal" T Cells Mediate Potent Anti-leukemic Effects.

Georgiadis C, Preece R, Nickolay L, Etuk A, Petrova A, Ladon D, Danyi A, Humphryes-Kirilov N, Ajetunmobi A, Kim D, Kim JS, Qasim W. Georgiadis C, et al. Mol Ther. 2018 May 2;26(5):1215-1227. doi: 10.1016/j.ymthe.2018.02.025. Epub 2018 Mar 6. Mol Ther. 2018. PMID: 29605708 Free PMC article.

5

TCRαβ/CD3 disruption enables CD3-specific antileukemic T cell immunotherapy.

Rasaiyaah J, Georgiadis C, Preece R, Mock U, Qasim W. Rasaiyaah J, et al. Among authors: georgiadis c. JCI Insight. 2018 Jul 12;3(13):e99442. doi: 10.1172/jci.insight.99442. JCI Insight. 2018. PMID: 29997304 Free PMC article.

6

Safety and early efficacy outcomes for lentiviral fibroblast gene therapy in recessive dystrophic epidermolysis bullosa.

Lwin SM, Syed F, Di WL, Kadiyirire T, Liu L, Guy A, Petrova A, Abdul-Wahab A, Reid F, Phillips R, Elstad M, Georgiadis C, Aristodemou S, Lovell PA, McMillan JR, Mee J, Miskinyte S, Titeux M, Ozoemena L, Pramanik R, Serrano S, Rowles R, Maurin C, Orrin E, Martinez-Queipo M, Rashidghamat E, Tziotzios C, Onoufriadis A, Chen M, Chan L, Farzaneh F, Del Rio M, Tolar J, Bauer JW, Larcher F, Antoniou MN, Hovnanian A, Thrasher AJ, Mellerio JE, Qasim W, McGrath JA. Lwin SM, et al. Among authors: georgiadis c. JCI Insight. 2019 Jun 6;4(11):e126243. doi: 10.1172/jci.insight.126243. eCollection 2019 Jun 6. JCI Insight. 2019. PMID: 31167965 Free PMC article. Clinical Trial.

7

Human Mesenchymal Stromal Cells Engineered to Express Collagen VII Can Restore Anchoring Fibrils in Recessive Dystrophic Epidermolysis Bullosa Skin Graft Chimeras.

Petrova A, Georgiadis C, Fleck RA, Allison L, McGrath JA, Dazzi F, Di WL, Qasim W. Petrova A, et al. Among authors: georgiadis c. J Invest Dermatol. 2020 Jan;140(1):121-131.e6. doi: 10.1016/j.jid.2019.05.031. Epub 2019 Jul 19. J Invest Dermatol. 2020. PMID: 31326396 Free article.

8

'Mini' U6 Pol III promoter exhibits nucleosome redundancy and supports multiplexed coupling of CRISPR/Cas9 effects.

Preece R, Georgiadis C, Gkazi SA, Etuk A, Christi A, Qasim W. Preece R, et al. Among authors: georgiadis c. Gene Ther. 2020 Sep;27(9):451-458. doi: 10.1038/s41434-020-0142-z. Epub 2020 Mar 20. Gene Ther. 2020. PMID: 32203198

9

CD70 expression determines the therapeutic efficacy of expanded human regulatory T cells.

Arroyo Hornero R, Georgiadis C, Hua P, Trzupek D, He LZ, Qasim W, Todd JA, Ferreira RC, Wood KJ, Issa F, Hester J. Arroyo Hornero R, et al. Among authors: georgiadis c. Commun Biol. 2020 Jul 14;3(1):375. doi: 10.1038/s42003-020-1097-8. Commun Biol. 2020. PMID: 32665635 Free PMC article.

10

CRISPR-Mediated Base Conversion Allows Discriminatory Depletion of Endogenous T Cell Receptors for Enhanced Synthetic Immunity.

Preece R, Pavesi A, Gkazi SA, Stegmann KA, Georgiadis C, Tan ZM, Aw JYJ, Maini MK, Bertoletti A, Qasim W. Preece R, et al. Among authors: georgiadis c. Mol Ther Methods Clin Dev. 2020 Sep 11;19:149-161. doi: 10.1016/j.omtm.2020.09.002. eCollection 2020 Dec 11. Mol Ther Methods Clin Dev. 2020. PMID: 33102612 Free PMC article.

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