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Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.
Whitesell L, Robbins N, Huang DS, McLellan CA, Shekhar-Guturja T, LeBlanc EV, Nation CS, Hui R, Hutchinson A, Collins C, Chatterjee S, Trilles R, Xie JL, Krysan DJ, Lindquist S, Porco JA Jr, Tatu U, Brown LE, Pizarro J, Cowen LE. Whitesell L, et al. Among authors: cowen le. Nat Commun. 2019 Jan 24;10(1):402. doi: 10.1038/s41467-018-08248-w. Nat Commun. 2019. PMID: 30679438 Free PMC article.
Global proteomic analyses define an environmentally contingent Hsp90 interactome and reveal chaperone-dependent regulation of stress granule proteins and the R2TP complex in a fungal pathogen.
O'Meara TR, O'Meara MJ, Polvi EJ, Pourhaghighi MR, Liston SD, Lin ZY, Veri AO, Emili A, Gingras AC, Cowen LE. O'Meara TR, et al. Among authors: cowen le. PLoS Biol. 2019 Jul 8;17(7):e3000358. doi: 10.1371/journal.pbio.3000358. eCollection 2019 Jul. PLoS Biol. 2019. PMID: 31283755 Free PMC article.
Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.
Caplan T, Lorente-Macías Á, Stogios PJ, Evdokimova E, Hyde S, Wellington MA, Liston S, Iyer KR, Puumala E, Shekhar-Guturja T, Robbins N, Savchenko A, Krysan DJ, Whitesell L, Zuercher WJ, Cowen LE. Caplan T, et al. Among authors: cowen le. Cell Chem Biol. 2020 Mar 19;27(3):269-282.e5. doi: 10.1016/j.chembiol.2019.12.008. Epub 2020 Jan 7. Cell Chem Biol. 2020. PMID: 31924499 Free PMC article.
169 results