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Triptolide and its prodrug Minnelide target high-risk MYC-amplified medulloblastoma in preclinical models.
Rodriguez-Blanco J, Salvador AD, Suter RK, Swiderska-Syn M, Palomo-Caturla I, Kliebe V, Shahani P, Peterson K, Turos-Cabal M, Vieira ME, Wynn DT, Howell AJ, Yang F, Ban Y, McCrea HJ, Zindy F, Danis E, Vibhakar R, Jermakowicz A, Martin V, Coss CC, Harris BT, de Cubas A, Chen XS, Barnoud T, Roussel MF, Ayad NG, Robbins DJ. Rodriguez-Blanco J, et al. Among authors: robbins dj. J Clin Invest. 2024 Jun 17;134(15):e171136. doi: 10.1172/JCI171136. J Clin Invest. 2024. PMID: 38885332 Free PMC article.
Enhancing precision in colorectal cancer surgery: development of an LGR5-targeting RSPO1 peptide mimetic as a contrast agent for intraoperative fluorescence molecular imaging.
Parasido E, Ribeiro P, Chingle RM, Rohwetter T, Gupta N, Avetian G, Bladelli E, Pierobon M, Chen Y, Tang Q, Schnermann M, Rodriguez O, Robbins D, Burke TR Jr, Albanese C, Ihemelandu C. Parasido E, et al. Cell Cycle. 2024 Jul 10:1-12. doi: 10.1080/15384101.2024.2364578. Online ahead of print. Cell Cycle. 2024. PMID: 38984667 Free article.
Wnt signalosomes: What we know that we do not know.
Hartmann H, Siddiqui GS, Bryant J, Robbins DJ, Weiss VL, Ahmed Y, Lee E. Hartmann H, et al. Among authors: robbins dj. Bioessays. 2024 Nov 9:e2400110. doi: 10.1002/bies.202400110. Online ahead of print. Bioessays. 2024. PMID: 39520379 Review.
The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.
Ng VH, Spencer Z, Neitzel LR, Nayak A, Loberg MA, Shen C, Kassel SN, Kroh HK, An Z, Anthony CC, Bryant JM, Lawson A, Goldsmith L, Benchabane H, Hansen AG, Li J, D'Souza S, Lebensohn AM, Rohatgi R, Weiss WA, Weiss VL, Williams C, Hong CC, Robbins DJ, Ahmed Y, Lee E. Ng VH, et al. Among authors: robbins dj. Nat Commun. 2023 Oct 5;14(1):6173. doi: 10.1038/s41467-023-41836-z. Nat Commun. 2023. PMID: 37798301 Free PMC article.
The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6.
Spencer ZT, Ng VH, Benchabane H, Siddiqui GS, Duwadi D, Maines B, Bryant JM, Schwarzkopf A, Yuan K, Kassel SN, Mishra A, Pimentel A, Lebensohn AM, Rohatgi R, Gerber SA, Robbins DJ, Lee E, Ahmed Y. Spencer ZT, et al. Among authors: robbins dj. Nat Commun. 2023 Oct 5;14(1):6174. doi: 10.1038/s41467-023-41843-0. Nat Commun. 2023. PMID: 37798281 Free PMC article.
USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling.
Kassel S, Hanson AJ, Benchabane H, Saito-Diaz K, Cabel CR, Goldsmith L, Taha M, Kanuganti A, Ng VH, Xu G, Ye F, Picker J, Port F, Boutros M, Weiss VL, Robbins DJ, Thorne CA, Ahmed Y, Lee E. Kassel S, et al. Among authors: robbins dj. Sci Signal. 2023 Feb 7;16(771):eabn8372. doi: 10.1126/scisignal.abn8372. Epub 2023 Feb 7. Sci Signal. 2023. PMID: 36749823 Free PMC article.
150 results