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Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease.
Xu Y, Kuppe C, Perales-Patón J, Hayat S, Kranz J, Abdallah AT, Nagai J, Li Z, Peisker F, Saritas T, Halder M, Menzel S, Hoeft K, Kenter A, Kim H, van Roeyen CRC, Lehrke M, Moellmann J, Speer T, Buhl EM, Hoogenboezem R, Boor P, Jansen J, Knopp C, Kurth I, Smeets B, Bindels E, Reinders MEJ, Baan C, Gribnau J, Hoorn EJ, Steffens J, Huber TB, Costa I, Floege J, Schneider RK, Saez-Rodriguez J, Freedman BS, Kramann R. Xu Y, et al. Among authors: freedman bs. Nat Genet. 2022 Nov;54(11):1690-1701. doi: 10.1038/s41588-022-01202-z. Epub 2022 Oct 27. Nat Genet. 2022. PMID: 36303074 Free PMC article.
Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids.
Freedman BS, Brooks CR, Lam AQ, Fu H, Morizane R, Agrawal V, Saad AF, Li MK, Hughes MR, Werff RV, Peters DT, Lu J, Baccei A, Siedlecki AM, Valerius MT, Musunuru K, McNagny KM, Steinman TI, Zhou J, Lerou PH, Bonventre JV. Freedman BS, et al. Nat Commun. 2015 Oct 23;6:8715. doi: 10.1038/ncomms9715. Nat Commun. 2015. PMID: 26493500 Free PMC article.
Physiology assays in human kidney organoids.
Freedman BS. Freedman BS. Am J Physiol Renal Physiol. 2022 Jun 1;322(6):F625-F638. doi: 10.1152/ajprenal.00400.2021. Epub 2022 Apr 4. Am J Physiol Renal Physiol. 2022. PMID: 35379001 Free PMC article. Review.
Cyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity.
Grahammer F, Dumoulin B, Gulieva RE, Wu H, Xu Y, Sulaimanov N, Arnold F, Sandner L, Cordts T, Todkar A, Moulin P, Reichardt W, Puelles VG, Kramann R, Freedman BS, Busch H, Boerries M, Walz G, Huber TB. Grahammer F, et al. Among authors: freedman bs. Kidney Int. 2024 Nov;106(5):856-869. doi: 10.1016/j.kint.2024.08.021. Epub 2024 Aug 31. Kidney Int. 2024. PMID: 39218392 Free article.
61 results