Li XX - Search Results

1

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.

Albornoz EA, Amarilla AA, Modhiran N, Parker S, Li XX, Wijesundara DK, Aguado J, Zamora AP, McMillan CLD, Liang B, Peng NYG, Sng JDJ, Saima FT, Fung JN, Lee JD, Paramitha D, Parry R, Avumegah MS, Isaacs A, Lo MW, Miranda-Chacon Z, Bradshaw D, Salinas-Rebolledo C, Rajapakse NW, Wolvetang EJ, Munro TP, Rojas-Fernandez A, Young PR, Stacey KJ, Khromykh AA, Chappell KJ, Watterson D, Woodruff TM. Albornoz EA, et al. Among authors: li xx. Mol Psychiatry. 2023 Jul;28(7):2878-2893. doi: 10.1038/s41380-022-01831-0. Epub 2022 Nov 1. Mol Psychiatry. 2023. PMID: 36316366 Free PMC article.

2

New concepts on the therapeutic control of complement anaphylatoxin receptors.

Hawksworth OA, Li XX, Coulthard LG, Wolvetang EJ, Woodruff TM. Hawksworth OA, et al. Among authors: li xx. Mol Immunol. 2017 Sep;89:36-43. doi: 10.1016/j.molimm.2017.05.015. Epub 2017 May 30. Mol Immunol. 2017. PMID: 28576324 Review.

3

Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1.

Pandey S, Li XX, Srivastava A, Baidya M, Kumari P, Dwivedi H, Chaturvedi M, Ghosh E, Woodruff TM, Shukla AK. Pandey S, et al. Among authors: li xx. J Biol Chem. 2019 Jun 14;294(24):9416-9429. doi: 10.1074/jbc.RA119.007485. Epub 2019 Apr 29. J Biol Chem. 2019. PMID: 31036565 Free PMC article.

4

The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity.

Li XX, Lee JD, Kemper C, Woodruff TM. Li XX, et al. J Immunol. 2019 Jun 15;202(12):3339-3348. doi: 10.4049/jimmunol.1900371. J Immunol. 2019. PMID: 31160390 Review.

5

C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma.

Nabizadeh JA, Manthey HD, Panagides N, Steyn FJ, Lee JD, Li XX, Akhir FNM, Chen W, Boyle GM, Taylor SM, Woodruff TM, Rolfe BE. Nabizadeh JA, et al. Among authors: li xx. FASEB J. 2019 Oct;33(10):11060-11071. doi: 10.1096/fj.201800980RR. Epub 2019 Jul 12. FASEB J. 2019. PMID: 31298935

6

Emerging Insights into the Structure and Function of Complement C5a Receptors.

Pandey S, Maharana J, Li XX, Woodruff TM, Shukla AK. Pandey S, et al. Among authors: li xx. Trends Biochem Sci. 2020 Aug;45(8):693-705. doi: 10.1016/j.tibs.2020.04.004. Epub 2020 May 10. Trends Biochem Sci. 2020. PMID: 32402749 Review.

7

C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages.

Li XX, Clark RJ, Woodruff TM. Li XX, et al. J Immunol. 2020 Aug 15;205(4):1102-1112. doi: 10.4049/jimmunol.2000407. Epub 2020 Jul 1. J Immunol. 2020. PMID: 32611725

8

Pharmacological characterisation of small molecule C5aR1 inhibitors in human cells reveals biased activities for signalling and function.

Li XX, Lee JD, Massey NL, Guan C, Robertson AAB, Clark RJ, Woodruff TM. Li XX, et al. Biochem Pharmacol. 2020 Oct;180:114156. doi: 10.1016/j.bcp.2020.114156. Epub 2020 Jul 17. Biochem Pharmacol. 2020. PMID: 32682759

9

The "C3aR Antagonist" SB290157 is a Partial C5aR2 Agonist.

Li XX, Kumar V, Clark RJ, Lee JD, Woodruff TM. Li XX, et al. Front Pharmacol. 2021 Jan 21;11:591398. doi: 10.3389/fphar.2020.591398. eCollection 2020. Front Pharmacol. 2021. PMID: 33551801 Free PMC article.

10

Anaphylatoxin receptor promiscuity for commonly used complement C5a peptide agonists.

Li XX, Clark RJ, Woodruff TM. Li XX, et al. Int Immunopharmacol. 2021 Nov;100:108074. doi: 10.1016/j.intimp.2021.108074. Epub 2021 Aug 25. Int Immunopharmacol. 2021. PMID: 34454293

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