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Page 1
Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming.
Ford DJ, Duggan NM, Fry SE, Ripoll-Rozada J, Agten SM, Liu W, Corcilius L, Hackeng TM, van Oerle R, Spronk HMH, Ashhurst AS, Mini Sasi V, Kaczmarski JA, Jackson CJ, Pereira PJB, Passioura T, Suga H, Payne RJ. Ford DJ, et al. Among authors: payne rj. J Med Chem. 2021 Jun 10;64(11):7853-7876. doi: 10.1021/acs.jmedchem.1c00651. Epub 2021 May 27. J Med Chem. 2021. PMID: 34044534
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.
Ashhurst AS, Tang AH, Fajtová P, Yoon MC, Aggarwal A, Bedding MJ, Stoye A, Beretta L, Pwee D, Drelich A, Skinner D, Li L, Meek TD, McKerrow JH, Hook V, Tseng CT, Larance M, Turville S, Gerwick WH, O'Donoghue AJ, Payne RJ. Ashhurst AS, et al. Among authors: payne rj. J Med Chem. 2022 Feb 24;65(4):2956-2970. doi: 10.1021/acs.jmedchem.1c01494. Epub 2021 Nov 3. J Med Chem. 2022. PMID: 34730959 Free PMC article.
Expressed Protein Selenoester Ligation.
Kulkarni SS, Watson EE, Maxwell JWC, Niederacher G, Johansen-Leete J, Huhmann S, Mukherjee S, Norman AR, Kriegesmann J, Becker CFW, Payne RJ. Kulkarni SS, et al. Among authors: payne rj. Angew Chem Int Ed Engl. 2022 May 9;61(20):e202200163. doi: 10.1002/anie.202200163. Epub 2022 Mar 9. Angew Chem Int Ed Engl. 2022. PMID: 35194928 Free PMC article.
Potent Bactericidal Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A.
Hawkins PME, Hoi DM, Cheung CY, Wang T, Quan D, Sasi VM, Liu DY, Linington RG, Jackson CJ, Oehlers SH, Cook GM, Britton WJ, Clausen T, Payne RJ. Hawkins PME, et al. Among authors: payne rj. J Med Chem. 2022 Mar 24;65(6):4893-4908. doi: 10.1021/acs.jmedchem.1c02122. Epub 2022 Mar 16. J Med Chem. 2022. PMID: 35293761
Antiviral cyclic peptides targeting the main protease of SARS-CoV-2.
Johansen-Leete J, Ullrich S, Fry SE, Frkic R, Bedding MJ, Aggarwal A, Ashhurst AS, Ekanayake KB, Mahawaththa MC, Sasi VM, Luedtke S, Ford DJ, O'Donoghue AJ, Passioura T, Larance M, Otting G, Turville S, Jackson CJ, Nitsche C, Payne RJ. Johansen-Leete J, et al. Among authors: payne rj. Chem Sci. 2022 Feb 28;13(13):3826-3836. doi: 10.1039/d1sc06750h. eCollection 2022 Mar 30. Chem Sci. 2022. PMID: 35432913 Free PMC article.
Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice.
Ashhurst AS, Johansen MD, Maxwell JWC, Stockdale S, Ashley CL, Aggarwal A, Siddiquee R, Miemczyk S, Nguyen DH, Mackay JP, Counoupas C, Byrne SN, Turville S, Steain M, Triccas JA, Hansbro PM, Payne RJ, Britton WJ. Ashhurst AS, et al. Among authors: payne rj. Nat Commun. 2022 Nov 15;13(1):6972. doi: 10.1038/s41467-022-34297-3. Nat Commun. 2022. PMID: 36379950 Free PMC article.
Probing Ligand Binding Sites on Large Proteins by Nuclear Magnetic Resonance Spectroscopy of Genetically Encoded Non-Canonical Amino Acids.
Ekanayake KB, Mahawaththa MC, Qianzhu H, Abdelkader EH, George J, Ullrich S, Murphy RB, Fry SE, Johansen-Leete J, Payne RJ, Nitsche C, Huber T, Otting G. Ekanayake KB, et al. Among authors: payne rj. J Med Chem. 2023 Apr 13;66(7):5289-5304. doi: 10.1021/acs.jmedchem.3c00222. Epub 2023 Mar 15. J Med Chem. 2023. PMID: 36920850
396 results