Lim NK - Search Results

1

Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.

Xu J, Grosslight S, Mack KA, Nguyen SC, Clagg K, Lim NK, Timmerman JC, Shen J, White NA, Sirois LE, Han C, Zhang H, Sigman MS, Gosselin F. Xu J, et al. Among authors: lim nk. J Am Chem Soc. 2022 Nov 16;144(45):20955-20963. doi: 10.1021/jacs.2c09917. Epub 2022 Nov 3. J Am Chem Soc. 2022. PMID: 36326518

2

Single-Step Synthesis of 5,6,7,8-Tetrahydroindolizines via Annulation of 2-Formylpiperidine and 1,3-Dicarbonyl Compounds.

Capomolla SS, Lim NK, Zhang H. Capomolla SS, et al. Among authors: lim nk. Org Lett. 2015 Jul 17;17(14):3564-7. doi: 10.1021/acs.orglett.5b01671. Epub 2015 Jul 1. Org Lett. 2015. PMID: 26132641

3

Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-Carbon Olefins via Enol Tosylation and Suzuki-Miyaura Coupling.

Li BX, Le DN, Mack KA, McClory A, Lim NK, Cravillion T, Savage S, Han C, Collum DB, Zhang H, Gosselin F. Li BX, et al. Among authors: lim nk. J Am Chem Soc. 2017 Aug 9;139(31):10777-10783. doi: 10.1021/jacs.7b05071. Epub 2017 Jul 26. J Am Chem Soc. 2017. PMID: 28715208 Free PMC article.

4

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-Carbon Olefins via a Syn-Elimination Approach.

Lim NK, Weiss P, Li BX, McCulley CH, Hare SR, Bensema BL, Palazzo TA, Tantillo DJ, Zhang H, Gosselin F. Lim NK, et al. Org Lett. 2017 Nov 17;19(22):6212-6215. doi: 10.1021/acs.orglett.7b03141. Epub 2017 Nov 8. Org Lett. 2017. PMID: 29115843

5

Synthesis of a Selective Estrogen Receptor Degrader via a Stereospecific Elimination Approach.

Lim NK, Cravillion T, Savage S, McClory A, Han C, Zhang H, DiPasquale A, Gosselin F. Lim NK, et al. Org Lett. 2018 Feb 16;20(4):1114-1117. doi: 10.1021/acs.orglett.8b00035. Epub 2018 Feb 3. Org Lett. 2018. PMID: 29397753

6

Two-Step Synthesis of 3,4-Dihydropyrrolopyrazinones from Ketones and Piperazin-2-ones.

Sandoval C, Lim NK, Zhang H. Sandoval C, et al. Among authors: lim nk. Org Lett. 2018 Feb 16;20(4):1252-1255. doi: 10.1021/acs.orglett.8b00197. Epub 2018 Feb 6. Org Lett. 2018. PMID: 29406723

7

Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin.

Savage S, McClory A, Zhang H, Cravillion T, Lim NK, Masui C, Robinson SJ, Han C, Ochs C, Rege PD, Gosselin F. Savage S, et al. Among authors: lim nk. J Org Chem. 2018 Oct 5;83(19):11571-11576. doi: 10.1021/acs.joc.8b01551. Epub 2018 Sep 20. J Org Chem. 2018. PMID: 30200756

8

Macrolactamization Approaches to Arylomycin Antibiotics Core.

Lim NK, Linghu X, Wong N, Zhang H, Sowell CG, Gosselin F. Lim NK, et al. Org Lett. 2019 Jan 4;21(1):147-151. doi: 10.1021/acs.orglett.8b03603. Epub 2018 Dec 19. Org Lett. 2019. PMID: 30565949

9

Stereocontrolled Synthesis of Arylomycin-Based Gram-Negative Antibiotic GDC-5338.

Wong N, Petronijević F, Hong AY, Linghu X, Kelly SM, Hou H, Cravillion T, Lim NK, Robinson SJ, Han C, Molinaro C, Sowell CG, Gosselin F. Wong N, et al. Among authors: lim nk. Org Lett. 2019 Nov 15;21(22):9099-9103. doi: 10.1021/acs.orglett.9b03481. Epub 2019 Oct 31. Org Lett. 2019. PMID: 31668077

10

Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.

Xu J, Lim NK, Timmerman JC, Shen J, Clagg K, Orcel U, Bigler R, Trachsel E, Meier R, White NA, Burkhard JA, Sirois LE, Tian Q, Angelaud R, Bachmann S, Zhang H, Gosselin F. Xu J, et al. Among authors: lim nk. Org Lett. 2023 May 19;25(19):3417-3422. doi: 10.1021/acs.orglett.3c00961. Epub 2023 May 10. Org Lett. 2023. PMID: 37162129

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